| pubmed-article:11912178 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C0524851 | lld:lifeskim |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C1517676 | lld:lifeskim |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C1516451 | lld:lifeskim |
| pubmed-article:11912178 | lifeskim:mentions | umls-concept:C1514623 | lld:lifeskim |
| pubmed-article:11912178 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11912178 | pubmed:dateCreated | 2002-3-25 | lld:pubmed |
| pubmed-article:11912178 | pubmed:abstractText | In Huntington's disease (HD), CAG repeats extend a glutamine tract in huntingtin to initiate the dominant loss of striatal neurons and chorea. Neuropathological changes include the formation of insoluble mutant N-terminal fragment, as nuclear/neuropil inclusions and filter-trap amyloid, which may either participate in the disease process or be a degradative by-product. In young Hdh knock-in mice, CAGs that expand the glutamine tract in mouse huntingtin to childhood-onset HD lengths lead to nuclear accumulation of full-length mutant huntingtin and later accumulation of insoluble fragment. Here we report late-onset neurodegeneration and gait deficits in older Hdh(Q111) knock-in mice, demonstrating that the nuclear phenotypes comprise early stages in a disease process that conforms to genetic and pathologic criteria determined in HD patients. Furthermore, using the early nuclear-accumulation phenotypes as surrogate markers, we show in genetic experiments that the disease process, initiated by full-length mutant protein, is hastened by co-expression of mutant fragment; therefore, accrual of insoluble-product in already compromised neurons may exacerbate pathogenesis. In contrast, timing of early disease events was not altered by normal huntingtin or by mutant caspase-1, two proteins shown to reduce inclusions and glutamine toxicity in other HD models. Thus, potential HD therapies in man might be directed at different levels: preventing the disease-initiating mechanism or slowing the subsequent progression of pathogenesis. | lld:pubmed |
| pubmed-article:11912178 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11912178 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11912178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11912178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11912178 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11912178 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11912178 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:MacDonaldMarc... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:GutekunstClai... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:BorcheltDavid... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:WheelerVaness... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:VrbanacVladim... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:LebelLori-Ann... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:SchillingGabr... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:HerschStevenS | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:FriedlanderRo... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:GusellaJames... | lld:pubmed |
| pubmed-article:11912178 | pubmed:author | pubmed-author:VonsattelJean... | lld:pubmed |
| pubmed-article:11912178 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11912178 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11912178 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:11912178 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11912178 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11912178 | pubmed:pagination | 633-40 | lld:pubmed |
| pubmed-article:11912178 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11912178 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11912178 | pubmed:articleTitle | Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. | lld:pubmed |
| pubmed-article:11912178 | pubmed:affiliation | Molecular Neurogenetics Unit and Molecular Neuropathology, Massachusetts General Hospital, Charlestown, MA 02129, USA. | lld:pubmed |
| pubmed-article:11912178 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11912178 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11912178 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:15194 | entrezgene:pubmed | pubmed-article:11912178 | lld:entrezgene |
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