| pubmed-article:11911819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C0003315 | lld:lifeskim |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C0007577 | lld:lifeskim |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C1336926 | lld:lifeskim |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:11911819 | lifeskim:mentions | umls-concept:C0009085 | lld:lifeskim |
| pubmed-article:11911819 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11911819 | pubmed:dateCreated | 2002-3-25 | lld:pubmed |
| pubmed-article:11911819 | pubmed:abstractText | Integrin-mediated adhesion is essential for the formation of stable contacts between T cells and antigen-presenting cells (APCs). We show that Vav1 controls integrin-mediated adhesion of thymocytes and T cells to ECM proteins and ICAM1 following TCR stimulation. In a peptide-specific system, Vav1 is required for T cell adhesion to peptide-loaded APCs. Intriguingly, TCR-induced cell adhesion and aggregation of integrins occurs independent of WASP. Whereas LFA-1 and actin caps colocalize in wasp(-/-) T cells in response to TCR stimulation, loss of WASP uncouples TCR caps from actin patches. Our data reveal a novel role for Vav1 and WASP in the regulation of TCR-induced integrin clustering and cell adhesion and show that integrin and TCR clustering are controlled by distinct pathways. | lld:pubmed |
| pubmed-article:11911819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11911819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911819 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11911819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11911819 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11911819 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:PenningerJose... | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:OhashiPamela... | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:SasakiTakehik... | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:ENGHHH | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:KrawczykConni... | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:Oliveira-dos-... | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:GriffithsEmil... | lld:pubmed |
| pubmed-article:11911819 | pubmed:author | pubmed-author:SnapperScottS | lld:pubmed |
| pubmed-article:11911819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11911819 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11911819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11911819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11911819 | pubmed:pagination | 331-43 | lld:pubmed |
| pubmed-article:11911819 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11911819 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11911819 | pubmed:articleTitle | Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. | lld:pubmed |
| pubmed-article:11911819 | pubmed:affiliation | Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada. | lld:pubmed |
| pubmed-article:11911819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11911819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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