pubmed-article:11902729 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C0085494 | lld:lifeskim |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C1522538 | lld:lifeskim |
pubmed-article:11902729 | lifeskim:mentions | umls-concept:C0162724 | lld:lifeskim |
pubmed-article:11902729 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:11902729 | pubmed:dateCreated | 2002-3-20 | lld:pubmed |
pubmed-article:11902729 | pubmed:abstractText | The vanB gene cluster mediates glycopeptide resistance by production of peptidoglycan precursors ending in the depsipeptide D-alanyl-D-lactate (D-Ala-D-Lac) instead of D-Ala-D-Ala found in susceptible enterococci. Synthesis of D-Ala-D-Lac and hydrolysis of D-Ala-D-Ala is controlled by the VanR(B)S(B) two-component regulatory system that activates transcription of the resistance genes in response to vancomycin but not to teicoplanin. Two substitutions (A3C-->G or D168-->Y) in the VanS(B) sensor kinase resulted in induction by teicoplanin, indicating that the N-terminal domain of the protein was involved in glycopeptide sensing. A substitution (T237-->K) located in the vicinity of the putative autophosphorylation site of VanS(B) (H233) was associated with a constitutive phenotype and affected a conserved residue known to be critical for the phosphatase activity of related kinases. A mutant producing an impaired host D-Ala:D-Ala ligase required vancomycin for growth, since D-Ala-D-Lac was only produced under inducing conditions. The ddl and vanS(B) mutations, alone or in combination, resulted in various resistance phenotypes that were determined by the amount of D-Ala-D-Ala and D-Ala-D-Lac incorporated into peptidoglycan precursors under different inducing conditions. | lld:pubmed |
pubmed-article:11902729 | pubmed:language | eng | lld:pubmed |
pubmed-article:11902729 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11902729 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11902729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11902729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:11902729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11902729 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11902729 | pubmed:month | Jul | lld:pubmed |
pubmed-article:11902729 | pubmed:issn | 0950-382X | lld:pubmed |
pubmed-article:11902729 | pubmed:author | pubmed-author:ArthurMM | lld:pubmed |
pubmed-article:11902729 | pubmed:author | pubmed-author:ReynoldeBB | lld:pubmed |
pubmed-article:11902729 | pubmed:author | pubmed-author:CourvalinPP | lld:pubmed |
pubmed-article:11902729 | pubmed:author | pubmed-author:BaptistaMM | lld:pubmed |
pubmed-article:11902729 | pubmed:author | pubmed-author:DepardieuFF | lld:pubmed |
pubmed-article:11902729 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11902729 | pubmed:volume | 25 | lld:pubmed |
pubmed-article:11902729 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11902729 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11902729 | pubmed:pagination | 93-105 | lld:pubmed |
pubmed-article:11902729 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
pubmed-article:11902729 | pubmed:meshHeading | pubmed-meshheading:11902729... | lld:pubmed |
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pubmed-article:11902729 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:11902729 | pubmed:articleTitle | Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci. | lld:pubmed |
pubmed-article:11902729 | pubmed:affiliation | Unité des Agents Antibactériens, Centre National de la Recherche Scientifique EP J0058, Institut Pasteur, Paris, France. | lld:pubmed |
pubmed-article:11902729 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11902729 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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