| pubmed-article:11900778 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11900778 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11900778 | lifeskim:mentions | umls-concept:C0391470 | lld:lifeskim |
| pubmed-article:11900778 | lifeskim:mentions | umls-concept:C0684271 | lld:lifeskim |
| pubmed-article:11900778 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11900778 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:11900778 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:11900778 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11900778 | pubmed:dateCreated | 2002-3-19 | lld:pubmed |
| pubmed-article:11900778 | pubmed:abstractText | The rarest and least understood of the muscarinic receptors is the M5 subtype. Recombinant methods were used to create mutant mice with a deletion in the third intracellular loop of the M5 receptor gene. Salivation induced by the nonselective muscarinic agonist pilocarpine (1 mg/kg s.c.) was reduced in homozygous mutants from 15 to 60 min after injection as compared with wild-type mice. After 18-h food and water deprivation, drinking was increased in homozygous mutants, but feeding was not increased. The mutant and wild-type mice had similar responses in tests of open-field exploration, seizures induced by pilocarpine (300 mg/kg) or hypothermia induced by pilocarpine (1-3 mg/kg). These results indicate that M5 muscarinic receptors are important for fluid intake and suggest that M5 receptors are involved in slow secretory processes. | lld:pubmed |
| pubmed-article:11900778 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11900778 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11900778 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11900778 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11900778 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11900778 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11900778 | pubmed:month | May | lld:pubmed |
| pubmed-article:11900778 | pubmed:issn | 0091-3057 | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:LeppN RNR | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:TakeuchiJunic... | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:RoderJohnJ | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:FultonJamesJ | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:JiaZheng-ping... | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:Abramov-Newer... | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:JamotLaureL | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:CowardDavidD | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:RalphMartinM | lld:pubmed |
| pubmed-article:11900778 | pubmed:author | pubmed-author:YeomansJohnJ | lld:pubmed |
| pubmed-article:11900778 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11900778 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:11900778 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11900778 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11900778 | pubmed:pagination | 117-23 | lld:pubmed |
| pubmed-article:11900778 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:meshHeading | pubmed-meshheading:11900778... | lld:pubmed |
| pubmed-article:11900778 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11900778 | pubmed:articleTitle | Increased drinking in mutant mice with truncated M5 muscarinic receptor genes. | lld:pubmed |
| pubmed-article:11900778 | pubmed:affiliation | Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3. | lld:pubmed |
| pubmed-article:11900778 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11900778 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11900778 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:213788 | entrezgene:pubmed | pubmed-article:11900778 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11900778 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11900778 | lld:pubmed |
