| pubmed-article:11895757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11895757 | lifeskim:mentions | umls-concept:C0079744 | lld:lifeskim |
| pubmed-article:11895757 | lifeskim:mentions | umls-concept:C0282491 | lld:lifeskim |
| pubmed-article:11895757 | lifeskim:mentions | umls-concept:C1956267 | lld:lifeskim |
| pubmed-article:11895757 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:11895757 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:11895757 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11895757 | pubmed:dateCreated | 2002-3-15 | lld:pubmed |
| pubmed-article:11895757 | pubmed:abstractText | Recently we have identified subgroups of de novo primary diffuse large B-cell lymphoma (DLBCL) based on complementary DNA microarray-generated gene expression profiles. To correlate the gene expression profiles with cytogenetic abnormalities in these DLBCLs, we examined the occurrence of the t(14;18)(q32;q21) in the 2 distinctive subgroups of DLBCL: one with the germinal center B-cell gene expression signature and the other with the activated B cell-like gene expression signature. The t(14;18) was detected in 7 of 35 cases (20%). All 7 t(14;18)-positive cases had a germinal center B-cell gene expression profile, representing 35% of the cases in this subgroup, and 6 of these 7 cases had very similar gene expression profiles. The expression of bcl-2 and bcl-6 proteins was not significantly different between the t(14;18)-positive and -negative cases, whereas CD10 was detected only in the group with the germinal center B-cell expression profile, and CD10 was most frequently expressed in the t(14;18)-positive cases. This study supports the validity of subdividing DLBCL into 2 major subgroups by gene expression profiling, with the t(14;18) being an important event in the pathogenesis of a subset of DLBCL arising from germinal center B cells. CD10 protein expression is useful in identifying cases of DLBCL with a germinal center B-cell gene expression profile and is often expressed in cases with the t(14;18). | lld:pubmed |
| pubmed-article:11895757 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11895757 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11895757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11895757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11895757 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11895757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11895757 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11895757 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:WeisenburgerD... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:SangerWarren... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:AlizadehAsh... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:StaudtLouis... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:LevyRonaldR | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:LossosIzidore... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:WarnkeRoger... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:ChanWing CWC | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:ArmitageJames... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:PickeringDian... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:GreinerTimoth... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:HuangJames... | lld:pubmed |
| pubmed-article:11895757 | pubmed:author | pubmed-author:LynchJames... | lld:pubmed |
| pubmed-article:11895757 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11895757 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11895757 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:11895757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11895757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11895757 | pubmed:pagination | 2285-90 | lld:pubmed |
| pubmed-article:11895757 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
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| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:meshHeading | pubmed-meshheading:11895757... | lld:pubmed |
| pubmed-article:11895757 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11895757 | pubmed:articleTitle | The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile. | lld:pubmed |
| pubmed-article:11895757 | pubmed:affiliation | Department of Pathology, The Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198, USA. | lld:pubmed |
| pubmed-article:11895757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11895757 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11895757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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