| pubmed-article:11890694 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11890694 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:11890694 | lifeskim:mentions | umls-concept:C2339371 | lld:lifeskim |
| pubmed-article:11890694 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11890694 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11890694 | lifeskim:mentions | umls-concept:C1706907 | lld:lifeskim |
| pubmed-article:11890694 | lifeskim:mentions | umls-concept:C1506298 | lld:lifeskim |
| pubmed-article:11890694 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11890694 | pubmed:dateCreated | 2002-3-13 | lld:pubmed |
| pubmed-article:11890694 | pubmed:abstractText | This report describes for the first time a novel anionic background current (I(AB)) identified in guinea-pig isolated ventricular myocytes. It also shows that I(AB) has both novel and differential pharmacology from other (cardiac) chloride currents. Using the whole-cell patch-clamp technique and external anion substitution, I(AB) was found to be outwardly rectifying and highly permeable to NO(-)(3), with a relative permeability sequence of NO(-)(3) > I(-) > Cl(-). I(AB) was not blocked by 50 microM DIDS, by hypertonic external solution, or by the nonselective protein kinase inhibitor H7-DHC. Exposure to the pyrethroid agent tefluthrin (10 microM) increased the current density of I(AB) significantly at positive voltages (P < 0.05), but had no significant effect on other cardiac chloride currents. We conclude that I(AB) possesses a distinct pharmacology and does not fall into the three major classes of cardiac chloride conductance commonly reported. | lld:pubmed |
| pubmed-article:11890694 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11890694 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11890694 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11890694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11890694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11890694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11890694 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11890694 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11890694 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11890694 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:11890694 | pubmed:author | pubmed-author:HancoxJules... | lld:pubmed |
| pubmed-article:11890694 | pubmed:author | pubmed-author:BorgJohn JJJ | lld:pubmed |
| pubmed-article:11890694 | pubmed:author | pubmed-author:SpencerC... | lld:pubmed |
| pubmed-article:11890694 | pubmed:author | pubmed-author:KozlowskiRola... | lld:pubmed |
| pubmed-article:11890694 | pubmed:copyrightInfo | (C)2002 Elsevier Science (USA). | lld:pubmed |
| pubmed-article:11890694 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11890694 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:11890694 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:11890694 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11890694 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11890694 | pubmed:pagination | 208-15 | lld:pubmed |
| pubmed-article:11890694 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:meshHeading | pubmed-meshheading:11890694... | lld:pubmed |
| pubmed-article:11890694 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11890694 | pubmed:articleTitle | Tefluthrin modulates a novel anionic background conductance (I(AB)) in guinea-pig ventricular myocytes. | lld:pubmed |
| pubmed-article:11890694 | pubmed:affiliation | Department of Pharmacology, University of Bristol, Bristol, BS8 1TD, United Kingdom. | lld:pubmed |
| pubmed-article:11890694 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11890694 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11890694 | lld:pubmed |
