| pubmed-article:11888511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11888511 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:11888511 | lifeskim:mentions | umls-concept:C1882561 | lld:lifeskim |
| pubmed-article:11888511 | lifeskim:mentions | umls-concept:C0042396 | lld:lifeskim |
| pubmed-article:11888511 | lifeskim:mentions | umls-concept:C0360714 | lld:lifeskim |
| pubmed-article:11888511 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:11888511 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11888511 | pubmed:dateCreated | 2002-3-12 | lld:pubmed |
| pubmed-article:11888511 | pubmed:abstractText | Freshly solubilized A beta peptides synergistically increase the magnitude of the constriction induced by endothelin-1 (ET-1), via the activation of a pro-inflammatory pathway. We report that mevinolin and mevastatin, two inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are able to completely abolish the vasoactive properties of A beta in rat aortae. Mevinolin also appears to oppose the increased vascular reactivity to ET-1 induced by interleukin 1-beta and phospholipase A(2) suggesting that statins display some anti-inflammatory properties. We show that freshly solubilized A beta stimulates prostaglandin E(2) and F(2 alpha) production (by 6 and 3.6 times, respectively) in isolated rat aortae and that mevinolin completely antagonizes this effect confirming the anti-inflammatory action of mevinolin ex vivo in rat aortae. In addition, we observed that A beta vasoactivity is not mediated nor modulated by mevalonic acid suggesting that the anti-inflammatory action of the statins are not related to an inhibition of HMG-CoA reductase activity. Differentiated human neuroblastoma cells (IMR32) were used to assess the neurotoxic effect of pre-aggregated A beta by quantifying the release of lactate dehydrogenase (LDH) in the cell culture medium. A beta appears to enhance LDH release by 30% in IMR32 cells, an effect that can be completely opposed by mevastatin. Taken together these data show that statins can antagonize the effect of A beta in different assays and provide new clues to understand the prophylactic action of the statins against Alzheimer's disease. | lld:pubmed |
| pubmed-article:11888511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11888511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11888511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11888511 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11888511 | pubmed:issn | 0021-9150 | lld:pubmed |
| pubmed-article:11888511 | pubmed:author | pubmed-author:MullanMichael... | lld:pubmed |
| pubmed-article:11888511 | pubmed:author | pubmed-author:ParisDanielD | lld:pubmed |
| pubmed-article:11888511 | pubmed:author | pubmed-author:TownsendKirk... | lld:pubmed |
| pubmed-article:11888511 | pubmed:author | pubmed-author:HumphreyJames... | lld:pubmed |
| pubmed-article:11888511 | pubmed:author | pubmed-author:ObregonDemian... | lld:pubmed |
| pubmed-article:11888511 | pubmed:author | pubmed-author:YokotaKiyokoK | lld:pubmed |
| pubmed-article:11888511 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11888511 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:11888511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11888511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11888511 | pubmed:pagination | 293-9 | lld:pubmed |
| pubmed-article:11888511 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:meshHeading | pubmed-meshheading:11888511... | lld:pubmed |
| pubmed-article:11888511 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11888511 | pubmed:articleTitle | Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. | lld:pubmed |
| pubmed-article:11888511 | pubmed:affiliation | Department of Psychiatry, The Roskamp Institute, University of South Florida, 3515 E. Fletcher Avenue, Tampa, FL 33613, USA. dparis@hsc.usf.edu | lld:pubmed |
| pubmed-article:11888511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11888511 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11888511 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11888511 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11888511 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11888511 | lld:pubmed |
