| pubmed-article:11888087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0007120 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0152013 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0334001 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:11888087 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:11888087 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11888087 | pubmed:dateCreated | 2002-3-12 | lld:pubmed |
| pubmed-article:11888087 | pubmed:abstractText | We assessed the occurrence of atypical adenomatous hyperplasia (AAH) in whole lung lobes with primary cancer lesions. Following surgical resection, tissue specimens were sliced to a thickness of 4 mm (3,641 specimens from 61 cases; mean = 59.7 specimens per case). A total of 119 AAH foci were found and an association was evident in 25 (57%) of 44 adenocarcinomas, 3 (30%) of 10 squamous cell carcinomas, and 2 (29%) of 7 other lung cancers. Histologic evaluation showed that 108 AAH foci were categorized as low-grade and the other 11 as high-grade AAH. These 11 foci of high-grade AAH were present in 7 patients with adenocarcinoma, and in 1 patient there was a synchronous double primary lung adenocarcinoma. High-grade AAH was closely associated with bronchioloalveolar carcinoma (BAC) type adenocarcinoma, and low-grade AAH with non-BAC adenocarcinoma. The mean +/- SD Ki-67 labeling index in high-grade AAH (3.5%+/-2.9%) was significantly higher than for the low-grade index (1.4%+/-1.6%). We propose that foci of high- but not low-grade AAH may be potential precursor lesions of lung adenocarcinoma, especially with the BAC component. | lld:pubmed |
| pubmed-article:11888087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11888087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888087 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11888087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11888087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11888087 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11888087 | pubmed:issn | 0002-9173 | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:YonemitsuYosh... | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:NakashimaYuta... | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:SueishiKatsuo... | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:SugimachiKeiz... | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:SugioKenjiK | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:YoshinoIchiro... | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:KogaTakaomiT | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:HashimotoShui... | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:MatsuoYoshioY | lld:pubmed |
| pubmed-article:11888087 | pubmed:author | pubmed-author:Mojtahedzadeh... | lld:pubmed |
| pubmed-article:11888087 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11888087 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:11888087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11888087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11888087 | pubmed:pagination | 464-70 | lld:pubmed |
| pubmed-article:11888087 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:meshHeading | pubmed-meshheading:11888087... | lld:pubmed |
| pubmed-article:11888087 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11888087 | pubmed:articleTitle | Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia. | lld:pubmed |
| pubmed-article:11888087 | pubmed:affiliation | Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:11888087 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11888087 | lld:pubmed |
