| pubmed-article:11882996 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1149404 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11882996 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11882996 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11882996 | pubmed:dateCreated | 2002-3-8 | lld:pubmed |
| pubmed-article:11882996 | pubmed:abstractText | Herpes simplex viruses (HSV) are resistant to the antiviral action of interferon. However, the underlying mechanisms are not well understood. In this report, we show that unlike that of wild-type HSV-1, replication of the gamma 1 34.5 null mutants was significantly inhibited by exogenous interferon-alpha in cells devoid of interferon-alpha/beta genes. Using a series of gamma 1 34.5 deletion mutants, the domain required for interferon resistance was mapped to the region containing amino acids 146 to 263 in the gamma 1 34.5 protein. Interestingly, Val193 Glu and Phe195 Leu substitutions in the protein phosphatase 1 interacting motif of the gamma 1 34.5 protein rendered HSV-1 sensitive to interferon-alpha. Furthermore, gamma 1 34.5 null mutants were sensitive to interferon-alpha/beta in PKR+/+ but not in PKR-/- mouse embryo fibroblasts. These findings provide evidence that the gamma 1 34.5 protein contributes to HSV-1 resistance to interferon-alpha/beta by inhibiting PKR function. | lld:pubmed |
| pubmed-article:11882996 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882996 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11882996 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882996 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11882996 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11882996 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11882996 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:11882996 | pubmed:author | pubmed-author:ChengGG | lld:pubmed |
| pubmed-article:11882996 | pubmed:author | pubmed-author:FOXJ FJF | lld:pubmed |
| pubmed-article:11882996 | pubmed:author | pubmed-author:BrettM EME | lld:pubmed |
| pubmed-article:11882996 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11882996 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:11882996 | pubmed:volume | 290 | lld:pubmed |
| pubmed-article:11882996 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11882996 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11882996 | pubmed:pagination | 115-20 | lld:pubmed |
| pubmed-article:11882996 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11882996 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11882996 | pubmed:articleTitle | Val193 and Phe195 of the gamma 1 34.5 protein of herpes simplex virus 1 are required for viral resistance to interferon-alpha/beta. | lld:pubmed |
| pubmed-article:11882996 | pubmed:affiliation | Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA. | lld:pubmed |
| pubmed-article:11882996 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11882996 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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