| pubmed-article:11882974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0238301 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0205696 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C0035970 | lld:lifeskim |
| pubmed-article:11882974 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:11882974 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11882974 | pubmed:dateCreated | 2002-3-8 | lld:pubmed |
| pubmed-article:11882974 | pubmed:abstractText | Epstein-Barr virus (EBV) is known to be closely associated with the development of anaplastic nasopharyngeal carcinoma (NPC) in some malignancy endemic regions in South-East Asia. LMP1 gene is one of the EBV latent genes, which encodes a latent membrane protein. LMP1 gene is thought to be a classical oncogene since it morphologically transforms cells in vitro and induces tumors in experimental animals in vivo. LMP1 is one of a few genes which is expressed in NPC tissues. It was first shown that C-terminus of LMP1 gene obtained from NPC patients in South-East Asia contained a deletion of 30 base pairs (bp). However, this deleted LMP1 gene was then found in the EBV isolates persisting among healthy virus carriers and patients with other EBV-associated abnormalities from both NPC endemic and non-endemic regions. The aim of this investigation was to accomplish a molecular biological analysis of EBV LMP1 genes obtained from Russian NPC patients. To this end, the authors isolated and sequenced the LMP1 clones amplified from the tumor tissues from 7 NPC patients at the N. N. Blokhin Russian Cancer Research Center and primary blood lymphocytes (PBL) from 6 healthy donors. As a result, the authors could not find the deletion of the above-mentioned 30 bp in NPC LMP1 clones, but could in one healthy donor (PBL-2). A functional analysis revealed no significant differences between LMP1 variants with or without 30 bp deletion in their capacity to activate NF kappa B and jun/AP-1 transcription factors. Nevertheless, Russian NPC-derived LMP1 variants as compared with those from PBLs featured some specific amino acid exchanges. These data indicate that the 30 bp deletion of LMP1 gene is not a factor that predisposes to NPC in Russia. | lld:pubmed |
| pubmed-article:11882974 | pubmed:language | rus | lld:pubmed |
| pubmed-article:11882974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11882974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11882974 | pubmed:issn | 0869-6047 | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:HahnPP | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:GurtsevichV... | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:BelousovaN... | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:Müller-Lantzs... | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:PavlishO AOA | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:ArkhipovV VVV | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:NovikovaE VEV | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:ShcherbakL... | lld:pubmed |
| pubmed-article:11882974 | pubmed:author | pubmed-author:GrasserF AFA | lld:pubmed |
| pubmed-article:11882974 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11882974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11882974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11882974 | pubmed:pagination | 53-9 | lld:pubmed |
| pubmed-article:11882974 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11882974 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11882974 | pubmed:articleTitle | [Structural and functional features of Epstein-Barr virus LMP-1 gene in patients with anaplastic carcinoma of the nasopharynx in Russia]. | lld:pubmed |
| pubmed-article:11882974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11882974 | pubmed:publicationType | English Abstract | lld:pubmed |
