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pubmed-article:11879526pubmed:abstractTextAnalysis of any newly sequenced bacterial genome starts with the identification of protein-coding genes. Despite the accumulation of multiple complete genome sequences, which provide useful comparisons with close relatives among other organisms during the annotation process, accurate gene prediction remains quite difficult. A major reason for this situation is that genes are tightly packed in prokaryotes, resulting in frequent overlap. Thus, detection of translation initiation sites and/or selection of the correct coding regions remain difficult unless appropriate biological knowledge (about the structure of a gene) is imbedded in the approach.lld:pubmed
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pubmed-article:11879526pubmed:articleTitleRe-annotation of genome microbial coding-sequences: finding new genes and inaccurately annotated genes.lld:pubmed
pubmed-article:11879526pubmed:affiliationLaboratoire Génome et Informatique, Université de Versailles, 91034 Evry Cedex, France. scbocs@infobiogen.frlld:pubmed
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