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pubmed-article:11877543pubmed:abstractTextProtein S deficiency and mesenteric venous thrombosis have been described in association with ischemic and/or necrotic bowel. Thrombophilic familial protein S deficiency is known to be amplified by estrogen replacement therapy. Pancreatic ischemia studies have revealed elevated amylase and lipase levels but not hyperglucagonemia. We postulate that estrogen replacement therapy leading to mesenteric and pancreatic ischemia not only caused symptoms of ischemic bowel, but also pancreatic oversecretion of glucagon in a patient with protein S deficiency. Our specific aim was to assess thrombophilic interactions of estrogen replacement therapy and familial protein S deficiency leading to osteonecrosis, hyperglucagonemia, and diarrhea.lld:pubmed
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pubmed-article:11877543pubmed:authorpubmed-author:GlueckC JCJlld:pubmed
pubmed-article:11877543pubmed:authorpubmed-author:PhillipsH GHGlld:pubmed
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pubmed-article:11877543pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11877543pubmed:articleTitleEstrogen replacement in a protein S deficient patient leads to diarrhea, hyperglucagonemia, and osteonecrosis.lld:pubmed
pubmed-article:11877543pubmed:affiliationCholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.comlld:pubmed
pubmed-article:11877543pubmed:publicationTypeJournal Articlelld:pubmed
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