| pubmed-article:1187340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1187340 | lifeskim:mentions | umls-concept:C0018873 | lld:lifeskim |
| pubmed-article:1187340 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:1187340 | lifeskim:mentions | umls-concept:C1621907 | lld:lifeskim |
| pubmed-article:1187340 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1187340 | pubmed:dateCreated | 1976-1-26 | lld:pubmed |
| pubmed-article:1187340 | pubmed:abstractText | A DNA methylase has been purified 270-fold from HeLa cell nuclei by chromatography on DEAE-cellulose, phosphocellulose, and hydroxyapatite. The enzyme transfers methyl groups from S-adenosyl-L-methionine to cytosine residues in DNA. The sole product of the reaction has been identified as 5-methylcytosine. The enzyme is able to methylate homologous (HeLa) DNA, although to a lesser extent than heterologous DNA. This may be due to incomplete methylation of HeLa DNA synthesized in vivo. The HeLa enzyme can methylate single-stranded DNA, and does so to an extent three times greater than that of the corresponding double-stranded DNA. In single-stranded M. luteus DNA, at least 2.4% of the cytosine residues can be methylated in vitro by the enzyme. The enzyme also can methylate poly (dG-dC-dG-dC) and poly (dG, dC). Bilateral nearest neighbors to the 5-methylcytosine have been determined with M. luteus DNA in vitro and HeLa DNA in vivo. The 5' neighbor can be either G or C while the 3' neighbor is always G and this sequence is, thus, p(G/C)pmCpG. | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1187340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1187340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1187340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1187340 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1187340 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:1187340 | pubmed:author | pubmed-author:WeissbachAA | lld:pubmed |
| pubmed-article:1187340 | pubmed:author | pubmed-author:RoyP HPH | lld:pubmed |
| pubmed-article:1187340 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1187340 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:1187340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1187340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1187340 | pubmed:pagination | 1669-84 | lld:pubmed |
| pubmed-article:1187340 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:meshHeading | pubmed-meshheading:1187340-... | lld:pubmed |
| pubmed-article:1187340 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1187340 | pubmed:articleTitle | DNA methylase from HeLa cell nuclei. | lld:pubmed |
| pubmed-article:1187340 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1187340 | lld:pubmed |
