| pubmed-article:11867684 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C1299003 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11867684 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11867684 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11867684 | pubmed:dateCreated | 2002-2-27 | lld:pubmed |
| pubmed-article:11867684 | pubmed:abstractText | Topical application of plasmid DNA encoding IL-12 to the cornea of mice prior to ocular infection with Herpes simplex virus type 1 (HSV) results in diminished corneal immunoinflammatory lesions. Such herpetic stromal keratitis (HSK) reactions in humans represent an important cause of blindness. The effect of IL-12 pretreatment acted via inhibitory effects on corneal neovascularization rather than by inhibiting viral replication or the function of CD4(+) T cells that mediate HSK. The antiangiogenesis induced by IL-12 DNA application was mediated indirectly via the cytokine IFN-gamma and one or both of two chemokine molecules, IP-10 and MIG. Thus IL-12 DNA administration lacked modulatory effects on HSK in GKO mice, indicating the necessary involvement of IFN-gamma induction for antiangiogenesis. In contrast, exposure of GKO mice to IP-10 DNA did suppress the severity of HSK. Furthermore, treatment with specific antisera to IP-10 and MIG in HSV-infected mice abrogated the IL-12-induced inhibitory effect on lesion severity. Taken together, our data indicate that the HSV-induced ocular immunoinflammatory lesions can be modulated by IL-12 and that this effect results from chemokine inhibition of angiogenesis. The use of antiangiogenesis therapy might represent a useful control measure against HSK. | lld:pubmed |
| pubmed-article:11867684 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867684 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867684 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11867684 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867684 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11867684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867684 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11867684 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11867684 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:11867684 | pubmed:author | pubmed-author:RouseBarry... | lld:pubmed |
| pubmed-article:11867684 | pubmed:author | pubmed-author:HamiltonThoma... | lld:pubmed |
| pubmed-article:11867684 | pubmed:author | pubmed-author:LeeSujinS | lld:pubmed |
| pubmed-article:11867684 | pubmed:author | pubmed-author:ZhengMeiM | lld:pubmed |
| pubmed-article:11867684 | pubmed:author | pubmed-author:DeshpandeShil... | lld:pubmed |
| pubmed-article:11867684 | pubmed:author | pubmed-author:EoSeong KugSK | lld:pubmed |
| pubmed-article:11867684 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11867684 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:11867684 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11867684 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11867684 | pubmed:pagination | 469-76 | lld:pubmed |
| pubmed-article:11867684 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:meshHeading | pubmed-meshheading:11867684... | lld:pubmed |
| pubmed-article:11867684 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11867684 | pubmed:articleTitle | IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis. | lld:pubmed |
| pubmed-article:11867684 | pubmed:affiliation | Department of Microbiology, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996-0845, USA. | lld:pubmed |
| pubmed-article:11867684 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11867684 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11867684 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11867684 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11867684 | lld:pubmed |
