| pubmed-article:11867562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0206552 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11867562 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11867562 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11867562 | pubmed:dateCreated | 2002-2-27 | lld:pubmed |
| pubmed-article:11867562 | pubmed:abstractText | T cells that are intrathymically lineage committed are believed to maintain their CD4 or CD8 co-receptor expression. Here, we investigated whether intrathymic lineage commitment involves irreversible genetic modification or whether co-receptor expression can be reprogrammed depending on external stimuli. The CD4(+) T(h)1 clone 2D6 established from splenic T cells as an IL-12-dependent line survived in culture with IL-2, IL-7 or IL-15 alone. Surprisingly, CD8 expression occurred in 2D6 cells upon replacement of IL-12 with any one of the three cytokines that stimulate the common cytokine receptor gamma chain, yielding CD4(+)CD8(+) 2D6 cells. CD8 expression declined when IL-2 was replaced with IL-12 and CD8 induction was inhibited when IL-12 was included in IL-2 or IL-7 culture. Our observations show that even a lineage-committed mature T cell can be reprogrammed for co-receptor expression in response to particular external stimuli. | lld:pubmed |
| pubmed-article:11867562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11867562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11867562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11867562 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11867562 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:ParkWoong-Rye... | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:TomuraMichioM | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:ParkCheung-Se... | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:HamaokaToshiy... | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:FujiwaraHirom... | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:YangYi-FuYF | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:ZhouXu-YuXY | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:ToyookaKazuhi... | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:Yashiro-Ohtan... | lld:pubmed |
| pubmed-article:11867562 | pubmed:author | pubmed-author:TaiXu-GuangXG | lld:pubmed |
| pubmed-article:11867562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11867562 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:11867562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11867562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11867562 | pubmed:pagination | 259-66 | lld:pubmed |
| pubmed-article:11867562 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:meshHeading | pubmed-meshheading:11867562... | lld:pubmed |
| pubmed-article:11867562 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11867562 | pubmed:articleTitle | Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line. | lld:pubmed |
| pubmed-article:11867562 | pubmed:affiliation | Department of Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:11867562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11867562 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
