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pubmed-article:11865008pubmed:abstractTextKeratinocyte apoptosis is a major pathogenic mechanism in dermal complications, such as graft versus host disease (GVHD), after allogeneic bone marrow transplantation. However, the mechanisms by which recipient target cells undergo apoptosis in GVHD are still unclear, but may result from DNA damage caused by chemotherapeutic agents and/or by direct cytokine action. The basis of this investigation was to correlate keratinocyte apoptosis with (1) the severity of graft versus host reactions (GVHR) in vitro and (2) the clinical grade (0--III) of GVHD.lld:pubmed
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pubmed-article:11865008pubmed:articleTitleThe detection of apoptosis in a human in vitro skin explant assay for graft versus host reactions.lld:pubmed
pubmed-article:11865008pubmed:affiliationDepartment of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.lld:pubmed
pubmed-article:11865008pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11865008pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed