Linked Life Data

11859932

Source:http://linkedlifedata.com/resource/pubmed/id/11859932

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pubmed-article:11859932pubmed:abstractTextof this study was to test whether variation in mitochondrial composition is associated with "selective vulnerability" in Alzheimer brain. The term "selective vulnerability" refers to the loss of relatively vulnerable brain cells and the sparing of relatively resistant brain cells in disorders in which a genetic defect or environmental agent acts on both types of cells. The mechanisms underlying selective vulnerability are largely unknown, but mitochondria may be involved; the composition of mitochondria varies among different types of neurons, and mitochondria have an important role in cell death. Alzheimer's Disease (AD) is one of a number of neurodegenerative disorders in which both selective vulnerability and abnormalities of mitochondria occur.lld:pubmed
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pubmed-article:11859932pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11859932pubmed:articleTitleSelective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?lld:pubmed
pubmed-article:11859932pubmed:affiliationAltschul Laboratory for Dementia Research, Burke Medical Research Institute, Weill-Cornell Medical College, White Plains, NY, USA.lld:pubmed
pubmed-article:11859932pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11859932pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:11859932pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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