| pubmed-article:11858992 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11858992 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:11858992 | lifeskim:mentions | umls-concept:C0949665 | lld:lifeskim |
| pubmed-article:11858992 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11858992 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11858992 | pubmed:dateCreated | 2002-2-22 | lld:pubmed |
| pubmed-article:11858992 | pubmed:abstractText | Anti-HIV-1 activities and pharmacokinetics of a series of novel arylpiperazinyl fluoroquinolones are reported. Modification at the C-8 position with a trifluoromethyl group was superior to that with a difluoromethoxy group to achieve higher anti-HIV-1 activity. Two compounds studied exhibited quite high anti-HIV-1 activities (IC(50)<50 nM) in vitro and high bioavailabilities (BA>90%) in monkeys. | lld:pubmed |
| pubmed-article:11858992 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11858992 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858992 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11858992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858992 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11858992 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11858992 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:MahdiA AAA | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:IwamotoAikich... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:OhmineToshino... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:KatsubeTetsus... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:TsuzakiYasuno... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:KobayashiNobu... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:KomaiTomoakiT | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:HagiharaMasah... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:NishigakiTaka... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:KimuraTomioT | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:KashiwaseHiro... | lld:pubmed |
| pubmed-article:11858992 | pubmed:author | pubmed-author:YamashitaMako... | lld:pubmed |
| pubmed-article:11858992 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11858992 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:11858992 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:11858992 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11858992 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11858992 | pubmed:pagination | 739-42 | lld:pubmed |
| pubmed-article:11858992 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
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| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:meshHeading | pubmed-meshheading:11858992... | lld:pubmed |
| pubmed-article:11858992 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11858992 | pubmed:articleTitle | Anti-HIV-1 activities and pharmacokinetics of new arylpiperazinyl fluoroquinolones. | lld:pubmed |
| pubmed-article:11858992 | pubmed:affiliation | Biological Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, 140-8710, Tokyo, Japan. | lld:pubmed |
| pubmed-article:11858992 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11858992 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11858992 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11858992 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11858992 | lld:pubmed |
