| pubmed-article:11858989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C0034251 | lld:lifeskim |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:11858989 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11858989 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11858989 | pubmed:dateCreated | 2002-2-22 | lld:pubmed |
| pubmed-article:11858989 | pubmed:abstractText | The new thiosemicarbazones and thiocarbonohydrazones derived from 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane were synthesized and evaluated for their inhibitory effect on tumor cell proliferation and their antiviral and antimicrobial activity. Thiosemicarbazone inhibited tumor cell proliferation (GI50's range: 2.4-100 microM and mean GI50 43.9 microM against various human leukemic cell lines) while thiosemicarbazone and thiocarbonohydrazone 5d exhibited significant inhibition of tumor cell proliferation (GI50's range 2.3-23.6 microM and mean GI50 7.2 microM for and GI50's range 2.4-32.4 microM and mean GI50 12.8microM for ). These GI50 values are comparable to that of 2-acetylpyridine thiosemicarbazone an important lead in TSC's family. The compounds did not afford specific activity against any of the viruses tested when examined at non-toxic concentrations. A weak activity was found for thiocarbonohydrazones against Gram-(+) bacteria (MIC(50) 117.3 and 133 microM, respectively). Using a combination of molecular mechanics calculations and NOE spectroscopy it was shown that the parent compounds and have opposite configuration around C=N bond. Whether this difference in structure can be correlated with the biological activity will be investigated in future studies. | lld:pubmed |
| pubmed-article:11858989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11858989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11858989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11858989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11858989 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11858989 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:SnoeckRobertR | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:KolocourisAnt... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:DimasKostasK | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:PannecouqueCh... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:WitvrouwMyria... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:FoscolosGeorg... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:StamatiouGeor... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:FytasGeorgeG | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:ZoidisGrigori... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:KolocourisNic... | lld:pubmed |
| pubmed-article:11858989 | pubmed:author | pubmed-author:AndreiGraciel... | lld:pubmed |
| pubmed-article:11858989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11858989 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:11858989 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:11858989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11858989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11858989 | pubmed:pagination | 723-7 | lld:pubmed |
| pubmed-article:11858989 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:meshHeading | pubmed-meshheading:11858989... | lld:pubmed |
| pubmed-article:11858989 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11858989 | pubmed:articleTitle | New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation. | lld:pubmed |
| pubmed-article:11858989 | pubmed:affiliation | School of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, GR-15771, Athens, Greece. | lld:pubmed |
| pubmed-article:11858989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11858989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11858989 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11858989 | lld:pubmed |
