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pubmed-article:11858170pubmed:abstractTextEthanol abuse is the most prevalent cause of liver cirrhosis in Spain. Genetic polymorphisms affect the activity of the enzymes involved in ethanol metabolism and in processing the toxic by-products generated in the liver. N-acetyltransferase 2 (NAT2) is a polymorphic phase 2 enzyme not involved in these processes, but recent data suggest that the most prevalent slow acetylator genotype protects against the risk of advanced alcoholic liver disease (ALD). We have identified six single nucleotide polymorphisms (SNP) at the NAT2 gene locus in order to disclose whether such an association exists.lld:pubmed
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pubmed-article:11858170pubmed:articleTitleN-acetyltransferase 2 polymorphism is not related to the risk of advanced alcoholic liver disease.lld:pubmed
pubmed-article:11858170pubmed:affiliationDept of Pharmacology, School of Medicine, University of Extremadura, Badajoz, Spain.lld:pubmed
pubmed-article:11858170pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11858170pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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