| pubmed-article:11855810 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11855810 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:11855810 | lifeskim:mentions | umls-concept:C0282498 | lld:lifeskim |
| pubmed-article:11855810 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:11855810 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11855810 | pubmed:dateCreated | 2002-2-21 | lld:pubmed |
| pubmed-article:11855810 | pubmed:abstractText | The heat shock response is known to inhibit NF-kappaB activation and NF-kappaB-dependent gene expression. Herein we determined if cells lacking heat shock factor-1 (HSF-1), the major transcription factor regulating heat shock protein gene expression, have an altered ability to modulate NF-kappaB activation. Embryonic fibroblasts from HSF-1-null mutant mice (HSF-1-/- cells) had a drastically reduced ability to express heat shock protein-70 in response to heat shock, compared to embryonic fibroblasts from wild-type mice (HSF+/+ cells). There was no difference, however, in the ability of heat shock to inhibit TNFalpha-mediated NF-kappaB activation, IkappaBalpha degradation, IkappaB kinase activation, and macrophage chemotactic protein-1 expression in the HSF-1-/- cells compared to the HSF-1+/+ cells. These data demonstrate that heat shock inhibits activation of the NF-kappaB/IkappaBalpha pathway and NF-kappaB-dependent gene expression in the absence of an intact heat shock response. | lld:pubmed |
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| pubmed-article:11855810 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11855810 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11855810 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11855810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11855810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11855810 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11855810 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11855810 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:11855810 | pubmed:author | pubmed-author:MalhotraVivek... | lld:pubmed |
| pubmed-article:11855810 | pubmed:author | pubmed-author:ShanleyThomas... | lld:pubmed |
| pubmed-article:11855810 | pubmed:author | pubmed-author:WongHector... | lld:pubmed |
| pubmed-article:11855810 | pubmed:author | pubmed-author:Eaves-PylesTo... | lld:pubmed |
| pubmed-article:11855810 | pubmed:author | pubmed-author:OdomsKelliK | lld:pubmed |
| pubmed-article:11855810 | pubmed:author | pubmed-author:QuaidGinaG | lld:pubmed |
| pubmed-article:11855810 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11855810 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11855810 | pubmed:volume | 291 | lld:pubmed |
| pubmed-article:11855810 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11855810 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11855810 | pubmed:pagination | 453-7 | lld:pubmed |
| pubmed-article:11855810 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11855810 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11855810 | pubmed:articleTitle | Heat shock inhibits activation of NF-kappaB in the absence of heat shock factor-1. | lld:pubmed |
| pubmed-article:11855810 | pubmed:affiliation | Division of Critical Care Medicine, Children's Hospital Medical Center and Children's Hospital Research Foundation, Cincinnati, Ohio 45229-3039, USA. | lld:pubmed |
| pubmed-article:11855810 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11855810 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11855810 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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