| pubmed-article:11852084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11852084 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11852084 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:11852084 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11852084 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:11852084 | pubmed:dateCreated | 2002-2-19 | lld:pubmed |
| pubmed-article:11852084 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:abstractText | Siah-1, the human homologue of Drosophila seven in absentia, is related to apoptosis and tumor suppression. Although it was reported that the expression of Siah-1 is induced by p53 and p21/WAF1, little is known about the transcriptional regulation of the Siah-1 gene. To investigate the transcriptional regulation, we isolated and sequenced the genomic fragment of the Siah-1 promoter region. The Siah-1 promoter has no typical TATA box or CCAAT box. Transient transfection assays using reporter plasmids in which the promoter region of the Siah-1 gene was deleted or mutated showed that one Sp1 site was responsible for the basal promoter activity. In Northern blotting analysis, the expression of the Siah-1 gene was upregulated by p53, but activation of the reporter plasmid by the p53 co-transfection assay was not shown, suggesting that a p53 responsive element does not exist in the promoter region we examined in this study but might be present in another region. | lld:pubmed |
| pubmed-article:11852084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11852084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11852084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11852084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11852084 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11852084 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:11852084 | pubmed:author | pubmed-author:KusuzakiKatsu... | lld:pubmed |
| pubmed-article:11852084 | pubmed:author | pubmed-author:MaedaAyakaA | lld:pubmed |
| pubmed-article:11852084 | pubmed:author | pubmed-author:YoshidaTatsus... | lld:pubmed |
| pubmed-article:11852084 | pubmed:author | pubmed-author:SakaiToshiyuk... | lld:pubmed |
| pubmed-article:11852084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11852084 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:11852084 | pubmed:volume | 512 | lld:pubmed |
| pubmed-article:11852084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11852084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11852084 | pubmed:pagination | 223-6 | lld:pubmed |
| pubmed-article:11852084 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
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| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:meshHeading | pubmed-meshheading:11852084... | lld:pubmed |
| pubmed-article:11852084 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11852084 | pubmed:articleTitle | The characterization of the human Siah-1 promoter(1). | lld:pubmed |
| pubmed-article:11852084 | pubmed:affiliation | Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan. | lld:pubmed |
| pubmed-article:11852084 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11852084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6477 | entrezgene:pubmed | pubmed-article:11852084 | lld:entrezgene |
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