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pubmed-article:11851319pubmed:abstractTextWe have designed synthetic peptides corresponding to two different regions of the genome of foot-and-mouth disease virus (FMDV) that are effective as (a) a vaccine or (b) a diagnostic reagent which differentiates convalescent from vaccinated animals, respectively. The peptide vaccine is based on a sequence from the prominent G-H loop of VP1, one of the four capsid proteins. The sequence was optimized by the inclusion of a cyclic constraint and adjoining sequences, and broader immunogenicity was obtained by the incorporation of consensus residues at hypervariable positions. The peptide also included a promiscuous T-helper epitope for effective immunogenicity in outbred populations of large animals.The diagnostic reagent, a peptide based on non-structural (NS) protein 3B, is used in immuno-assays for the detection of antibodies. Antibodies to this NS protein are present in the sera of infected animals but not in the sera of vaccinated animals. The VP1 peptide can be used in complementary immuno-assays for confirmation of NS test results and to monitor for vaccination. This system for differential diagnosis is important to establish the disease-free status of a country.lld:pubmed
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pubmed-article:11851319pubmed:authorpubmed-author:ChangT YTYlld:pubmed
pubmed-article:11851319pubmed:authorpubmed-author:TAOS CSClld:pubmed
pubmed-article:11851319pubmed:authorpubmed-author:YangP CPClld:pubmed
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pubmed-article:11851319pubmed:authorpubmed-author:ChenS PSPlld:pubmed
pubmed-article:11851319pubmed:authorpubmed-author:WangC YCYlld:pubmed
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pubmed-article:11851319pubmed:authorpubmed-author:YuZZlld:pubmed
pubmed-article:11851319pubmed:authorpubmed-author:ZhangM LMLlld:pubmed
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pubmed-article:11851319pubmed:authorpubmed-author:FORDG DGDlld:pubmed
pubmed-article:11851319pubmed:copyrightInfoCopyright 2001 The International Association for Biologicals.lld:pubmed
pubmed-article:11851319pubmed:issnTypePrintlld:pubmed
pubmed-article:11851319pubmed:volume29lld:pubmed
pubmed-article:11851319pubmed:ownerNLMlld:pubmed
pubmed-article:11851319pubmed:authorsCompleteYlld:pubmed
pubmed-article:11851319pubmed:pagination221-8lld:pubmed
pubmed-article:11851319pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:11851319pubmed:articleTitleSynthetic peptide-based vaccine and diagnostic system for effective control of FMD.lld:pubmed
pubmed-article:11851319pubmed:affiliationUnited Biomedical Inc., 25 Davids Drive, Hauppauge, NY 11788, U.S.A. cywang@unitedbiomedical.comlld:pubmed
pubmed-article:11851319pubmed:publicationTypeJournal Articlelld:pubmed