| pubmed-article:11846975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11846975 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11846975 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11846975 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:11846975 | lifeskim:mentions | umls-concept:C0185027 | lld:lifeskim |
| pubmed-article:11846975 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11846975 | pubmed:dateCreated | 2002-2-15 | lld:pubmed |
| pubmed-article:11846975 | pubmed:abstractText | Recent molecular, biochemical, and gene disruption studies have demonstrated the essential role of interferon (IFN) regulatory factor-3, (IRF-3) and IRF-7 in the activation of type I IFN gene expression and the induction of the antiviral state. Both transcription factors share structural and functional properties, as well as a common mechanism of activation through C-terminal phosphorylation. The purpose of this review is to summarize recent investigations indicating that similar signalling pathways are likely involved in the activation of IRF-3 and IRF-7. Moreover, unique biochemical events, such as coactivator association and differential recognition of cis-acting elements, also illustrate the capacity of IRF-3 and IRF-7 to selectively regulate type I IFN and IFN-stimulated gene (ISG) expression. | lld:pubmed |
| pubmed-article:11846975 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11846975 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11846975 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11846975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11846975 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11846975 | pubmed:issn | 1079-9907 | lld:pubmed |
| pubmed-article:11846975 | pubmed:author | pubmed-author:ServantMarc... | lld:pubmed |
| pubmed-article:11846975 | pubmed:author | pubmed-author:TenoeverBenja... | lld:pubmed |
| pubmed-article:11846975 | pubmed:author | pubmed-author:LinRongtuanR | lld:pubmed |
| pubmed-article:11846975 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11846975 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:11846975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11846975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11846975 | pubmed:pagination | 49-58 | lld:pubmed |
| pubmed-article:11846975 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11846975 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11846975 | pubmed:articleTitle | Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function. | lld:pubmed |
| pubmed-article:11846975 | pubmed:affiliation | Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Medicine, McGill University, Montreal, Canada. | lld:pubmed |
| pubmed-article:11846975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11846975 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:11846975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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