| pubmed-article:11846974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11846974 | lifeskim:mentions | umls-concept:C1706474 | lld:lifeskim |
| pubmed-article:11846974 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:11846974 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:11846974 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:11846974 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11846974 | pubmed:dateCreated | 2002-2-15 | lld:pubmed |
| pubmed-article:11846974 | pubmed:abstractText | Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers. | lld:pubmed |
| pubmed-article:11846974 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11846974 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11846974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11846974 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11846974 | pubmed:issn | 1079-9907 | lld:pubmed |
| pubmed-article:11846974 | pubmed:author | pubmed-author:RomeoGiovanna... | lld:pubmed |
| pubmed-article:11846974 | pubmed:author | pubmed-author:FiorucciGiann... | lld:pubmed |
| pubmed-article:11846974 | pubmed:author | pubmed-author:ChiantoreMari... | lld:pubmed |
| pubmed-article:11846974 | pubmed:author | pubmed-author:PercarioZulem... | lld:pubmed |
| pubmed-article:11846974 | pubmed:author | pubmed-author:VannucchiSere... | lld:pubmed |
| pubmed-article:11846974 | pubmed:author | pubmed-author:AffabrisElisa... | lld:pubmed |
| pubmed-article:11846974 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11846974 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:11846974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11846974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11846974 | pubmed:pagination | 39-47 | lld:pubmed |
| pubmed-article:11846974 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11846974 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11846974 | pubmed:articleTitle | IRF-1 as a negative regulator of cell proliferation. | lld:pubmed |
| pubmed-article:11846974 | pubmed:affiliation | Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy. romeo@iss.it | lld:pubmed |
| pubmed-article:11846974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11846974 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:11846974 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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