| pubmed-article:11842185 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11842185 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:11842185 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11842185 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:11842185 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11842185 | pubmed:dateCreated | 2002-2-20 | lld:pubmed |
| pubmed-article:11842185 | pubmed:abstractText | The dynamic properties of the inositol (1,4,5)-trisphosphate (IP(3)) receptor are crucial for the control of intracellular Ca(2+), including the generation of Ca(2+) oscillations and waves. However, many models of this receptor do not agree with recent experimental data on the dynamic responses of the receptor. We construct a model of the IP(3) receptor and fit the model to dynamic and steady-state experimental data from type-2 IP(3) receptors. Our results indicate that, (i) Ca(2+) binds to the receptor using saturating, not mass-action, kinetics; (ii) Ca(2+) decreases the rate of IP(3) binding while simultaneously increasing the steady-state sensitivity of the receptor to IP(3); (iii) the rate of Ca(2+)-induced receptor activation increases with Ca(2+) and is faster than Ca(2+)-induced receptor inactivation; and (iv) IP(3) receptors are sequentially activated and inactivated by Ca(2+) even when IP(3) is bound. Our results emphasize that measurement of steady-state properties alone is insufficient to characterize the functional properties of the receptor. | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11842185 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11842185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11842185 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11842185 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11842185 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11842185 | pubmed:author | pubmed-author:DufourJean-Fr... | lld:pubmed |
| pubmed-article:11842185 | pubmed:author | pubmed-author:SneydJamesJ | lld:pubmed |
| pubmed-article:11842185 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11842185 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11842185 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:11842185 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11842185 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11842185 | pubmed:pagination | 2398-403 | lld:pubmed |
| pubmed-article:11842185 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:meshHeading | pubmed-meshheading:11842185... | lld:pubmed |
| pubmed-article:11842185 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11842185 | pubmed:articleTitle | A dynamic model of the type-2 inositol trisphosphate receptor. | lld:pubmed |
| pubmed-article:11842185 | pubmed:affiliation | Institute of Information and Mathematical Sciences, Massey University, Albany Campus, Private Bag 102-904, North Shore Mail Centre, Auckland, New Zealand. jsneyd@massey.ac.nz | lld:pubmed |
| pubmed-article:11842185 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11842185 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11842185 | lld:pubmed |
