| pubmed-article:11839753 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11839753 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:11839753 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11839753 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:11839753 | lifeskim:mentions | umls-concept:C0008013 | lld:lifeskim |
| pubmed-article:11839753 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:11839753 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11839753 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:11839753 | pubmed:dateCreated | 2002-4-15 | lld:pubmed |
| pubmed-article:11839753 | pubmed:abstractText | The effects of cholesterol-perturbing agents on the mobilization of calcium induced upon the stimulation of human neutrophils by chemotactic factors were tested. Methyl-beta-cyclodextrin and filipin did not alter the initial peak of calcium mobilization but shortened the duration of the calcium spike that followed the addition of fMet-Leu-Phe. These agents also inhibited the influx of Mn(2+) induced by fMet-Leu-Phe or thapsigargin. Methyl-beta-cyclodextrin and filipin completely abrogated the mobilization of calcium induced by 10(-10) m platelet-activating factor, which at this concentration depends to a major extent on an influx of calcium as well as the influx of calcium induced by 10(-7) m platelet-activating factor. On the other hand, methyl-beta-cyclodextrin and filipin enhanced the mobilization of calcium induced by ligation of FcgammaRIIA, an agonist that did not induce a detectable influx of calcium. Finally, methyl-beta-cyclodextrin and filipin enhanced the stimulation of the profile of tyrosine phosphorylation, the activity of phospholipase D (PLD), and the production of superoxide anions induced by fMet-Leu-Phe. These results suggest that the calcium channels utilized by chemotactic factors in human neutrophils are either located in cholesterol-rich regions of the plasma membrane, or that the mechanisms that lead to their opening depend on the integrity of these microdomains. | lld:pubmed |
| pubmed-article:11839753 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11839753 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839753 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11839753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11839753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11839753 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11839753 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11839753 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11839753 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11839753 | pubmed:author | pubmed-author:NaccachePaul... | lld:pubmed |
| pubmed-article:11839753 | pubmed:author | pubmed-author:BourgoinSylva... | lld:pubmed |
| pubmed-article:11839753 | pubmed:author | pubmed-author:BarabéFrédéri... | lld:pubmed |
| pubmed-article:11839753 | pubmed:author | pubmed-author:FernandesMari... | lld:pubmed |
| pubmed-article:11839753 | pubmed:author | pubmed-author:ParéGuillaume... | lld:pubmed |
| pubmed-article:11839753 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11839753 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11839753 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11839753 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11839753 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11839753 | pubmed:pagination | 13473-8 | lld:pubmed |
| pubmed-article:11839753 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11839753 | pubmed:meshHeading | pubmed-meshheading:11839753... | lld:pubmed |
| pubmed-article:11839753 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11839753 | pubmed:articleTitle | Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils. | lld:pubmed |
| pubmed-article:11839753 | pubmed:affiliation | Canadian Institutes for Health Research group on the Molecular Mechanisms of Inflammation, Department of Medicine, Laval University, Québec, G1V 4G2 Canada. | lld:pubmed |
| pubmed-article:11839753 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11839753 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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