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pubmed-article:11834904pubmed:abstractTextThymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels in transitional cell carcinoma of the bladder resected from 38 patients were examined by ELISA. TP levels in high-grade and invasive cancer were significantly higher than those in low-grade and superficial cancer, respectively. No significant differences in the DPD levels were observed among grades and stages, but the DPD/TP ratio was significantly lower in grade 3 tumor than in grade 1. These results demonstrated that 5'-deoxy-5-fluorouridine seemed to be useful for managing patients with grade 3 cancer. The present study also suggested that we might be able to exclude cases of bladder cancer in which 5-fluorouracil group medicines would be inappropriate candidates in treatment options by measuring both TP and DPD levels in the tumor.lld:pubmed
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pubmed-article:11834904pubmed:authorpubmed-author:IizumiTatsuoTlld:pubmed
pubmed-article:11834904pubmed:authorpubmed-author:HariuKyouichi...lld:pubmed
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pubmed-article:11834904pubmed:authorpubmed-author:ShimizuHirofu...lld:pubmed
pubmed-article:11834904pubmed:authorpubmed-author:TomomasaHiros...lld:pubmed
pubmed-article:11834904pubmed:authorpubmed-author:UmedaTakashiTlld:pubmed
pubmed-article:11834904pubmed:copyrightInfoCopyright 2002 S. Karger AG, Basellld:pubmed
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pubmed-article:11834904pubmed:volume68lld:pubmed
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pubmed-article:11834904pubmed:pagination122-5lld:pubmed
pubmed-article:11834904pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11834904pubmed:articleTitleThymidine phosphorylase and dihydropyrimidine dehydrogenase in bladder cancer.lld:pubmed
pubmed-article:11834904pubmed:affiliationDepartment of Urology, Teikyo University School of Medicine, Tokyo, Japan. urology@med.teikyo-u.ac.jplld:pubmed
pubmed-article:11834904pubmed:publicationTypeJournal Articlelld:pubmed