pubmed-article:11823447 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11823447 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:11823447 | lifeskim:mentions | umls-concept:C0016410 | lld:lifeskim |
pubmed-article:11823447 | lifeskim:mentions | umls-concept:C0266453 | lld:lifeskim |
pubmed-article:11823447 | lifeskim:mentions | umls-concept:C1413430 | lld:lifeskim |
pubmed-article:11823447 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
pubmed-article:11823447 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
pubmed-article:11823447 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:11823447 | pubmed:dateCreated | 2002-2-1 | lld:pubmed |
pubmed-article:11823447 | pubmed:abstractText | Cited2 (also Mrg1/p35srj) is a member of a new conserved gene family that is expressed during mouse development and in adult tissues. In order to investigate the function of Cited2 during mouse embryogenesis, we introduced a null mutation into the Cited2 locus. Cited2(-/-) mutants died at late gestation and exhibited heart defects and exencephaly, arising from defective closure of the midbrain (MB) and hindbrain. Initiation of neural tube closure at the forebrain-midbrain (FB-MB) boundary, an essential step for closure of the cranial neural tube, was impaired in the Cited2(-/-) mutants. Gene marker analysis using in situ hybridization revealed that the patterning of the anterior neural plate and head mesenchyme was little affected or normal in the Cited2(-/-) embryos. However, Cited2 was required for the survival of neuroepithelial cells and its absence led to massive apoptosis in dorsal neuroectoderm around the FB-MB boundary and in a restricted transverse domain in the hindbrain. Treatment with folic acid significantly reduced the exencephalic phenotype in the Cited2(-/-) embryos both in vivo and in vitro. However, assessment of folate metabolism revealed no defect in the Cited2(-/-) mutants, and the elevated apoptosis observed in the neuroepithelium of the Cited2(-/-) mutants was apparently not decreased by folic acid supplementation. To our knowledge, the Cited2 mouse represents the first genetic model in which folic acid can prevent a defect in neural tube closure by a mechanism other than the neutralization of a defect in folate homeostasis. | lld:pubmed |
pubmed-article:11823447 | pubmed:language | eng | lld:pubmed |
pubmed-article:11823447 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11823447 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11823447 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:11823447 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11823447 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11823447 | pubmed:month | Feb | lld:pubmed |
pubmed-article:11823447 | pubmed:issn | 0964-6906 | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:DunwoodieSall... | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:CoppAndrew... | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:RAUSTGG | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:BarberaJuan... | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:RodriguezTris... | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:GreeneNichola... | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:SimeoneAntoni... | lld:pubmed |
pubmed-article:11823447 | pubmed:author | pubmed-author:BeddingtonRos... | lld:pubmed |
pubmed-article:11823447 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11823447 | pubmed:day | 1 | lld:pubmed |
pubmed-article:11823447 | pubmed:volume | 11 | lld:pubmed |
pubmed-article:11823447 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11823447 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11823447 | pubmed:pagination | 283-93 | lld:pubmed |
pubmed-article:11823447 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:11823447 | pubmed:meshHeading | pubmed-meshheading:11823447... | lld:pubmed |
pubmed-article:11823447 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:11823447 | pubmed:articleTitle | Folic acid prevents exencephaly in Cited2 deficient mice. | lld:pubmed |
pubmed-article:11823447 | pubmed:affiliation | MRC Centre for Developmental Neurobiology, 4th floor New Hunt's House, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK. juan.martinez-barbera@kcl.ac.uk | lld:pubmed |
pubmed-article:11823447 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11823447 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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