| pubmed-article:11814856 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11814856 | lifeskim:mentions | umls-concept:C0000507 | lld:lifeskim |
| pubmed-article:11814856 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:11814856 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:11814856 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:11814856 | lifeskim:mentions | umls-concept:C1175965 | lld:lifeskim |
| pubmed-article:11814856 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11814856 | pubmed:dateCreated | 2002-1-29 | lld:pubmed |
| pubmed-article:11814856 | pubmed:abstractText | Various 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one 1 derivatives have been synthesized and tested as inhibitors of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver. The inhibition results indicated that well-positioned dicarbonyl groups as well as the cyclopropyl group of 1 were essential for potent inhibition. Substitution at the 2-position of the ring system has a significant effect on inhibitor potency, while the 5-position can undergo substantial variations and retain inhibitor potency. In the compounds examined, 2-chloro substituted 12 is the best inhibitor of all with IC(50) of 15 nM, the rest of the synthesized analogues were less potent inhibitors than the parent compound. | lld:pubmed |
| pubmed-article:11814856 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11814856 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814856 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11814856 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11814856 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:11814856 | pubmed:author | pubmed-author:LinYung-LungY... | lld:pubmed |
| pubmed-article:11814856 | pubmed:author | pubmed-author:WuChung-Shieh... | lld:pubmed |
| pubmed-article:11814856 | pubmed:author | pubmed-author:LinShean-Woei... | lld:pubmed |
| pubmed-article:11814856 | pubmed:author | pubmed-author:HuangJian-Lin... | lld:pubmed |
| pubmed-article:11814856 | pubmed:author | pubmed-author:SunYang-Sheng... | lld:pubmed |
| pubmed-article:11814856 | pubmed:author | pubmed-author:YangDing-YahD... | lld:pubmed |
| pubmed-article:11814856 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11814856 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:11814856 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11814856 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11814856 | pubmed:pagination | 685-90 | lld:pubmed |
| pubmed-article:11814856 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:meshHeading | pubmed-meshheading:11814856... | lld:pubmed |
| pubmed-article:11814856 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11814856 | pubmed:articleTitle | SAR studies of 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. | lld:pubmed |
| pubmed-article:11814856 | pubmed:affiliation | Department of Chemistry, Tunghai University, 181, Taichung-Kang Rd. Sec. 3, Taichung, Taiwan 40704, ROC. | lld:pubmed |
| pubmed-article:11814856 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11814856 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
