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pubmed-article:11814816pubmed:abstractTextSynthesis and SARs of new integrin alpha(V)beta(3) antagonists based on an N-substituted dibenzazepinone scaffold are described. Variation of spacer and guanidine mimetic led to potent compounds exhibiting an IC(50) towards alpha(V)beta(3) in the nanomolar range, high selectivity versus integrin alpha(IIb)beta(3) and efficacy in functional cellular assays.lld:pubmed
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pubmed-article:11814816pubmed:articleTitleSynthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists.lld:pubmed
pubmed-article:11814816pubmed:affiliationKnoll GmbH, D-67008 Ludwigshafen, Germany. andreas.kling@abbott.delld:pubmed
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