| pubmed-article:11801724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11801724 | lifeskim:mentions | umls-concept:C0596981 | lld:lifeskim |
| pubmed-article:11801724 | lifeskim:mentions | umls-concept:C1167069 | lld:lifeskim |
| pubmed-article:11801724 | lifeskim:mentions | umls-concept:C0021699 | lld:lifeskim |
| pubmed-article:11801724 | lifeskim:mentions | umls-concept:C0037799 | lld:lifeskim |
| pubmed-article:11801724 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:11801724 | lifeskim:mentions | umls-concept:C1416877 | lld:lifeskim |
| pubmed-article:11801724 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:11801724 | pubmed:dateCreated | 2002-1-21 | lld:pubmed |
| pubmed-article:11801724 | pubmed:abstractText | Mutations in the genes encoding the inner nuclear membrane proteins lamin A/C and emerin produce cardiomyopathy and muscular dystrophy in humans and mice. The mechanism by which these broadly expressed gene products result in tissue-specific dysfunction is not known. We have identified a protein of the inner nuclear membrane that is highly expressed in striated and smooth muscle. This protein, myne-1 (myocyte nuclear envelope), is predicted to have seven spectrin repeats, an interrupted LEM domain and a single transmembrane domain at its C-terminus. We found that myne-1 is expressed upon early muscle differentiation in multiple intranuclear foci concomitant with lamin A/C expression. In mature muscle, myne-1 and lamin A/C are perfectly colocalized, although colocalization with emerin is only partial. Moreover, we show that myne-1 and lamin A/C coimmunoprecipitate from differentiated muscle in vitro. The muscle-specific inner nuclear envelope expression of myne-1, along with its interaction with lamin A/C, indicates that this gene is a potential mediator of cardiomyopathy and muscular dystrophy. | lld:pubmed |
| pubmed-article:11801724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11801724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11801724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11801724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11801724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11801724 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11801724 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:11801724 | pubmed:author | pubmed-author:MislowJohn... | lld:pubmed |
| pubmed-article:11801724 | pubmed:author | pubmed-author:KimMarian SMS | lld:pubmed |
| pubmed-article:11801724 | pubmed:author | pubmed-author:DavisDawn... | lld:pubmed |
| pubmed-article:11801724 | pubmed:author | pubmed-author:McNallyElizab... | lld:pubmed |
| pubmed-article:11801724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11801724 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11801724 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:11801724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11801724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11801724 | pubmed:pagination | 61-70 | lld:pubmed |
| pubmed-article:11801724 | pubmed:dateRevised | 2004-11-18 | lld:pubmed |
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| pubmed-article:11801724 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11801724 | pubmed:articleTitle | Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. | lld:pubmed |
| pubmed-article:11801724 | pubmed:affiliation | Department of Pathology, The University of Chicago, Chicago, IL 60637, USA. | lld:pubmed |
| pubmed-article:11801724 | pubmed:publicationType | Journal Article | lld:pubmed |
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