Linked Life Data

11796357

Source:http://linkedlifedata.com/resource/pubmed/id/11796357

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pubmed-article:11796357pubmed:abstractTextCaspofungin is an antifungal agent of the novel echinocandin class. We investigated its efficacy, safety, and tolerability as therapy for oropharyngeal and/or esophageal candidiasis in a phase II dose-ranging study. Patients were randomized in a double-blind manner to receive either caspofungin acetate (35, 50, or 70 mg) or amphotericin B (0.5 mg/kg of body weight) intravenously once daily for 7 to 14 days. A favorable response required both complete resolution of symptoms and quantifiable improvement of mucosal lesions 3 to 4 days after discontinuation of study drug. Efficacy was assessed using a modified intent-to-treat analysis. No hypothesis testing of efficacy was planned or performed. Of 140 enrolled patients, 63% had esophageal involvement and 98% were infected with the human immunodeficiency virus (HIV) (median CD4 count, 30/mm(3)). A modestly higher proportion of patients in each of the caspofungin groups (74 to 91%) achieved favorable responses compared to amphotericin B recipients (63%), but there was considerable overlap in the 95% confidence intervals surrounding these point estimates. Similar trends were found in the subgroups with esophageal involvement, a history of fluconazole failure, and CD4 counts of < or =50/mm(3). A smaller proportion of patients receiving any dose of caspofungin experienced drug-related adverse events compared to patients given standard doses of conventional amphotericin B (P < 0.01). Caspofungin provided a generally well-tolerated parenteral therapeutic option for HIV-infected patients with oropharyngeal and/or esophageal candidiasis in this study.lld:pubmed
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pubmed-article:11796357pubmed:authorpubmed-author:ArathoonEduar...lld:pubmed
pubmed-article:11796357pubmed:authorpubmed-author:GotuzzoEduard...lld:pubmed
pubmed-article:11796357pubmed:authorpubmed-author:NoriegaL...lld:pubmed
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pubmed-article:11796357pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:11796357pubmed:articleTitleRandomized, double-blind, multicenter study of caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiases.lld:pubmed
pubmed-article:11796357pubmed:affiliationHospital General San Juan de Dios, Guatemala City, Guatemala.lld:pubmed
pubmed-article:11796357pubmed:publicationTypeJournal Articlelld:pubmed
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