| pubmed-article:11793379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11793379 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11793379 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:11793379 | lifeskim:mentions | umls-concept:C1257852 | lld:lifeskim |
| pubmed-article:11793379 | lifeskim:mentions | umls-concept:C0020835 | lld:lifeskim |
| pubmed-article:11793379 | lifeskim:mentions | umls-concept:C0001561 | lld:lifeskim |
| pubmed-article:11793379 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11793379 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11793379 | pubmed:dateCreated | 2002-1-16 | lld:pubmed |
| pubmed-article:11793379 | pubmed:abstractText | Concanavalin A-immobilized polystyrene nanospheres (Con A-NS) were developed for the HIV-1 vaccine capable of preventing sexual transmission. Con A-NS could capture efficiently HIV-1 irrespective of their cell tropism (R5 or X4). Furthermore, Con A-NS captured equally infectious and heat-inactivated HIV-1. Inactivated HIV-1-capturing Con A-NS (HIV-NS) were intravaginally administered to mice. Heat-inactivated HIV-1 alone and Con A-NS alone were also administered as control immunogens. Vaginal fluids were collected during and after immunization and analyzed for their anti-HIV-1 antibody levels. Although the anti-HIV-1 IgG antibody was undetectable in any groups, increased anti-HIV-1 IgA antibody response was identified in the vaginal fluids of immunized mice with HIV-NS. The vaginal fluids obtained from the HIV-NS-administered mice showed neutralizing activity against the immunizing HIV-1 strain. A marked difference in vaginal distribution was observed between HIV-NS and other immunogens, and the toxicity of Con A was reduced by conjugation with nanospheres. Thus, HIV-NS may have great potential as a prophylactic HIV-1 vaccine and should be examined further for its efficacy in non-human primates. | lld:pubmed |
| pubmed-article:11793379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11793379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11793379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11793379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11793379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11793379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11793379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11793379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11793379 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11793379 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:SerizawaTakes... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:AkashiMitsuru... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:KawamuraMasak... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:NaitoTaichiT | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:UenoMasamichi... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:AkagiTakamiT | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:HiraishiKatsu... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:TakaiIzumiI | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:MakinoMasahik... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:SugimuraKazuh... | lld:pubmed |
| pubmed-article:11793379 | pubmed:author | pubmed-author:BabaMasanoriM | lld:pubmed |
| pubmed-article:11793379 | pubmed:copyrightInfo | Copyright 2002 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11793379 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11793379 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:11793379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11793379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11793379 | pubmed:pagination | 291-8 | lld:pubmed |
| pubmed-article:11793379 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
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| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:meshHeading | pubmed-meshheading:11793379... | lld:pubmed |
| pubmed-article:11793379 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11793379 | pubmed:articleTitle | Induction of mucosal IgA following intravaginal administration of inactivated HIV-1-capturing nanospheres in mice. | lld:pubmed |
| pubmed-article:11793379 | pubmed:affiliation | Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan. | lld:pubmed |
| pubmed-article:11793379 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11793379 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11793379 | lld:pubmed |
