| pubmed-article:11774337 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11774337 | lifeskim:mentions | umls-concept:C0031760 | lld:lifeskim |
| pubmed-article:11774337 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:11774337 | lifeskim:mentions | umls-concept:C1704448 | lld:lifeskim |
| pubmed-article:11774337 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:11774337 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:11774337 | lifeskim:mentions | umls-concept:C0023721 | lld:lifeskim |
| pubmed-article:11774337 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11774337 | pubmed:dateCreated | 2002-1-4 | lld:pubmed |
| pubmed-article:11774337 | pubmed:abstractText | Protein kinase C (PKC) desensitizes the light response in photoreceptors from the ventral optic nerve of the horseshoe crab Limulus. Photoisomerization of Limulus rhodopsin leads to phosphoinositide hydrolysis, resulting in the production of inositol trisphosphate and diacylglycerol (DAG). Inositol trisphosphate mobilizes intracellular stores of Ca(2+), resulting in photoreceptor excitation in Limulus, while DAG may activate PKC. We investigated whether PKC-mediated desensitization of the photoresponse is accompanied by ultrastructural changes in the rhodopsin-bearing photosensitive membrane (rhabdom) in Limulus ventral photoreceptors. PKC activation by (-)-indolactam V in darkness induces disorganization and swelling of the rhodopsin-containing microvilli and endocytosis of rhabdomeral membrane. The effects of (-)-indolactam V on dark-adapted photoreceptor ultrastructure are reversible, are stereospecific, are blocked by coapplication of PKC inhibitors, and closely match those induced by continuous, bright light. Rhabdom disorganization and endocytosis via PKC activation may, therefore, contribute to desensitization of the light-adapted photoreceptor. | lld:pubmed |
| pubmed-article:11774337 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11774337 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774337 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11774337 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11774337 | pubmed:issn | 0021-9967 | lld:pubmed |
| pubmed-article:11774337 | pubmed:author | pubmed-author:DabdoubAlainA | lld:pubmed |
| pubmed-article:11774337 | pubmed:author | pubmed-author:PayneRichardR | lld:pubmed |
| pubmed-article:11774337 | pubmed:author | pubmed-author:JinksRobert... | lld:pubmed |
| pubmed-article:11774337 | pubmed:copyrightInfo | Copyright 2001 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11774337 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11774337 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:11774337 | pubmed:volume | 442 | lld:pubmed |
| pubmed-article:11774337 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11774337 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11774337 | pubmed:pagination | 217-25 | lld:pubmed |
| pubmed-article:11774337 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
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| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
| pubmed-article:11774337 | pubmed:meshHeading | pubmed-meshheading:11774337... | lld:pubmed |
| pubmed-article:11774337 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11774337 | pubmed:articleTitle | Protein kinase C-induced disorganization and endocytosis of photosensitive membrane in Limulus ventral photoreceptors. | lld:pubmed |
| pubmed-article:11774337 | pubmed:affiliation | National Institutes of Health, NIDCD, Rockville, Maryland 20850, USA. | lld:pubmed |
| pubmed-article:11774337 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11774337 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
