| pubmed-article:11774077 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C0019381 | lld:lifeskim |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C0376387 | lld:lifeskim |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C1504389 | lld:lifeskim |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11774077 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:11774077 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11774077 | pubmed:dateCreated | 2002-1-4 | lld:pubmed |
| pubmed-article:11774077 | pubmed:abstractText | Human herpesvirus 6 (HHV-6) appears to cause central nervous system (CNS) syndromes, especially in hematopoietic stem cell transplant (HSCT) recipients. We reviewed our experience with HHV-6-associated CNS disease to evaluate both the clinical and virological presentation and response to antiviral therapy. A search of our virology database from January 1998 through June 2000 identified 11 HSCT recipients who had HHV-6 DNA detected by polymerase chain reaction in cerebrospinal fluid (CSF); 8 of whom had CNS dysfunction without another clear etiology identified. HHV-6 levels in serum and CSF were evaluated before and after ganciclovir and/or foscarnet therapy. Median log HHV-6 CSF levels appeared to decrease over time concurrent with antiviral therapy (serum level, 2.0 vs. 0 copies/mL [P=.38]; CSF level, 4.4 vs. 2.0 copies/mL [P=.13], sign test). Our data suggests that HHV-6 may cause moderate to severe CNS disease after HSC transplantation. Prospective studies are needed to define the spectrum of HHV-6-associated disease and to determine whether antiviral therapy offers clinical benefit. | lld:pubmed |
| pubmed-article:11774077 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774077 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774077 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774077 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11774077 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774077 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11774077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774077 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11774077 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11774077 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11774077 | pubmed:issn | 1537-6591 | lld:pubmed |
| pubmed-article:11774077 | pubmed:author | pubmed-author:CoreyLawrence... | lld:pubmed |
| pubmed-article:11774077 | pubmed:author | pubmed-author:HuangMeei-LiM... | lld:pubmed |
| pubmed-article:11774077 | pubmed:author | pubmed-author:ZerrDanielle... | lld:pubmed |
| pubmed-article:11774077 | pubmed:author | pubmed-author:GuptaDeeptiD | lld:pubmed |
| pubmed-article:11774077 | pubmed:author | pubmed-author:CarterRachelR | lld:pubmed |
| pubmed-article:11774077 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11774077 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11774077 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:11774077 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11774077 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11774077 | pubmed:pagination | 309-17 | lld:pubmed |
| pubmed-article:11774077 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11774077 | pubmed:meshHeading | pubmed-meshheading:11774077... | lld:pubmed |
| pubmed-article:11774077 | pubmed:meshHeading | pubmed-meshheading:11774077... | lld:pubmed |
| pubmed-article:11774077 | pubmed:meshHeading | pubmed-meshheading:11774077... | lld:pubmed |
| pubmed-article:11774077 | pubmed:meshHeading | pubmed-meshheading:11774077... | lld:pubmed |
| pubmed-article:11774077 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11774077 | pubmed:articleTitle | Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. | lld:pubmed |
| pubmed-article:11774077 | pubmed:affiliation | Department of Pediatrics, University of Washington, Seattle, WA, USA. zerr@u.washington.edu | lld:pubmed |
| pubmed-article:11774077 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11774077 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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