| pubmed-article:11748278 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11748278 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:11748278 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11748278 | pubmed:dateCreated | 2001-12-18 | lld:pubmed |
| pubmed-article:11748278 | pubmed:abstractText | Activation of tumor-associated CD8(+) cytotoxic T lymphocytes (CTLs) often requires antigen representation, e.g., by dendritic cells (DCs), and CD4(+) T cell help. Previously, we showed that CTL-mediated tumor immunity required interleukin 4 (IL-4) during the immunization but not effector phase. To determine the source and target cells of IL-4, we performed adoptive T cell transfers using CD4(+) and CD8(+) T cells from IL-4(-/-) and IL-4R(-/-) mice and analyzed CTL generation. Even though necessary for CTL generation, CD4(+) T cells did not need to express IL-4 or IL-4R. Surprisingly, CTL generation required IL-4 but not IL-4R expression by CD8(+) T cells. As IL-4 (a) was expressed by naive CD8(+) T cells within 24 h after antigen encounter, (b) IL-4 induced DC maturation, and (c) CTL development was impaired in T cell-reconstituted IL-4R(-/-) mice, CD8(+) T cell-derived IL-4 appears to act on DCs. We conclude that CD4(+) and CD8(+) T cells provide different signals for DC activation during CTL generation. | lld:pubmed |
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| pubmed-article:11748278 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11748278 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748278 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11748278 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11748278 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11748278 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11748278 | pubmed:author | pubmed-author:BlankensteinT... | lld:pubmed |
| pubmed-article:11748278 | pubmed:author | pubmed-author:PreissSS | lld:pubmed |
| pubmed-article:11748278 | pubmed:author | pubmed-author:Noben-TrauthN... | lld:pubmed |
| pubmed-article:11748278 | pubmed:author | pubmed-author:SchülerTT | lld:pubmed |
| pubmed-article:11748278 | pubmed:author | pubmed-author:KammertoensTT | lld:pubmed |
| pubmed-article:11748278 | pubmed:author | pubmed-author:DebsPP | lld:pubmed |
| pubmed-article:11748278 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11748278 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:11748278 | pubmed:volume | 194 | lld:pubmed |
| pubmed-article:11748278 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11748278 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11748278 | pubmed:pagination | 1767-75 | lld:pubmed |
| pubmed-article:11748278 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11748278 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11748278 | pubmed:articleTitle | Generation of tumor-associated cytotoxic T lymphocytes requires interleukin 4 from CD8(+) T cells. | lld:pubmed |
| pubmed-article:11748278 | pubmed:affiliation | Max-Delbrück-Center for Molecular Medicine, 13092 Berlin, Germany. tschue@mdc-berlin.de | lld:pubmed |
| pubmed-article:11748278 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11748278 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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