| pubmed-article:11748251 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C0242608 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C0754136 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11748251 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11748251 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11748251 | pubmed:dateCreated | 2001-12-28 | lld:pubmed |
| pubmed-article:11748251 | pubmed:abstractText | Centrosomes mature as cells enter mitosis, accumulating gamma-tubulin and other pericentriolar material (PCM) components. This occurs concomitant with an increase in the number of centrosomally organized microtubules (MTs). Here, we use RNA-mediated interference (RNAi) to examine the role of the aurora-A kinase, AIR-1, during centrosome maturation in Caenorhabditis elegans. In air-1(RNAi) embryos, centrosomes separate normally, an event that occurs before maturation in C. elegans. After nuclear envelope breakdown, the separated centrosomes collapse together, and spindle assembly fails. In mitotic air-1(RNAi) embryos, centrosomal alpha-tubulin fluorescence intensity accumulates to only 40% of wild-type levels, suggesting a defect in the maturation process. Consistent with this hypothesis, we find that AIR-1 is required for the increase in centrosomal gamma-tubulin and two other PCM components, ZYG-9 and CeGrip, as embryos enter mitosis. Furthermore, the AIR-1-dependent increase in centrosomal gamma-tubulin does not require MTs. These results suggest that aurora-A kinases are required to execute a MT-independent pathway for the recruitment of PCM during centrosome maturation. | lld:pubmed |
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| pubmed-article:11748251 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11748251 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748251 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11748251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11748251 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11748251 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11748251 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:11748251 | pubmed:author | pubmed-author:HymanA AAA | lld:pubmed |
| pubmed-article:11748251 | pubmed:author | pubmed-author:OegemaKK | lld:pubmed |
| pubmed-article:11748251 | pubmed:author | pubmed-author:KirkhamMM | lld:pubmed |
| pubmed-article:11748251 | pubmed:author | pubmed-author:HannamCC | lld:pubmed |
| pubmed-article:11748251 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11748251 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:11748251 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:11748251 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11748251 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11748251 | pubmed:pagination | 1109-16 | lld:pubmed |
| pubmed-article:11748251 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
| pubmed-article:11748251 | pubmed:meshHeading | pubmed-meshheading:11748251... | lld:pubmed |
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| pubmed-article:11748251 | pubmed:meshHeading | pubmed-meshheading:11748251... | lld:pubmed |
| pubmed-article:11748251 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11748251 | pubmed:articleTitle | Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:11748251 | pubmed:affiliation | Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. | lld:pubmed |
| pubmed-article:11748251 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11748251 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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