| pubmed-article:11748220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11748220 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:11748220 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:11748220 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:11748220 | lifeskim:mentions | umls-concept:C1421652 | lld:lifeskim |
| pubmed-article:11748220 | lifeskim:mentions | umls-concept:C1658578 | lld:lifeskim |
| pubmed-article:11748220 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11748220 | pubmed:dateCreated | 2002-2-18 | lld:pubmed |
| pubmed-article:11748220 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:abstractText | One hallmark of inflammation is the proliferation of bystander cells such as vascular smooth muscle cells (SMC), a process governed by growth factors and cytokines. Whereas cytokine induction of gene products promoting inflammation and proliferation is well characterized, little is known about the concomitant down-regulation of potentially counter-regulatory gene products in these cells. By employing the suppression subtractive hybridization-PCR technique, RNA isolated from rat aortic SMC treated with the cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) was subtracted from RNA of control cells. Eleven genes were identified, the expression of which fell by 44-77%. One, the transcriptional repressor splicing factor-1 or zfm1, was characterized further. Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory effects of IL-1 beta and TNF alpha on SMC proliferation and expression of the chemokine MCP-1 and the vascular cell adhesion molecule-1. Moreover, in an in vivo mouse model of atherosclerosis, zfm1 abundance was decreased in proliferating arterial SMC. These findings suggest a role for zfm1 in controlling both proliferation and expression of pro-inflammatory gene products in SMC. Therefore, cytokine-induced down-regulation of zfm1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases. | lld:pubmed |
| pubmed-article:11748220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11748220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11748220 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11748220 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11748220 | pubmed:author | pubmed-author:HeckerMarkusM | lld:pubmed |
| pubmed-article:11748220 | pubmed:author | pubmed-author:CattaruzzaMar... | lld:pubmed |
| pubmed-article:11748220 | pubmed:author | pubmed-author:SchäferKatrin... | lld:pubmed |
| pubmed-article:11748220 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11748220 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:11748220 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11748220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11748220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11748220 | pubmed:pagination | 6582-9 | lld:pubmed |
| pubmed-article:11748220 | pubmed:dateRevised | 2004-12-3 | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:meshHeading | pubmed-meshheading:11748220... | lld:pubmed |
| pubmed-article:11748220 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11748220 | pubmed:articleTitle | Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. | lld:pubmed |
| pubmed-article:11748220 | pubmed:affiliation | Department of Cardiovascular Physiology, University of Göttingen, Humboldtallee 23, 37073 Göttingen, Germany. | lld:pubmed |
| pubmed-article:11748220 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:114635 | entrezgene:pubmed | pubmed-article:11748220 | lld:entrezgene |
| entrez-gene:114636 | entrezgene:pubmed | pubmed-article:11748220 | lld:entrezgene |
| entrez-gene:114637 | entrezgene:pubmed | pubmed-article:11748220 | lld:entrezgene |
| entrez-gene:117855 | entrezgene:pubmed | pubmed-article:11748220 | lld:entrezgene |
| entrez-gene:293589 | entrezgene:pubmed | pubmed-article:11748220 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11748220 | lld:pubmed |
