| pubmed-article:11747827 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C0200635 | lld:lifeskim |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C0679932 | lld:lifeskim |
| pubmed-article:11747827 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11747827 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:11747827 | pubmed:dateCreated | 2001-12-18 | lld:pubmed |
| pubmed-article:11747827 | pubmed:abstractText | Striking cell losses occur during late B lymphocyte maturation, reflecting BcR-mediated selection coupled with requisites for viability promoting signals. How selection and survival cues are integrated remains unclear, but a key role for B lymphocyte stimulator (BLyS(TM); trademark of Human Genome Sciences, Inc.) is suggested by its marked effects on B cell numbers and autoantibody formation as well as the B lineage-specific expression of BLyS receptors. Our analyses of the B cell-deficient A/WySnJ mouse have established Bcmd as a gene controlling follicular B cell life span, and recent reports show Bcmd encodes a novel BLyS receptor. Here we show that A/WySnJ B cells are unresponsive to BLyS, affording interrogation of how Bcmd influences B cell homeostasis. Mixed marrow chimeras indicate A/WySnJ peripheral B cells compete poorly for peripheral survival. Moreover, in vivo BrdU labeling shows that (A/WySnJ x BALB/c)F(1) B cells have an intermediate but uniform life span, indicating viability requires continuous signaling via this pathway. Together, these findings establish the BLyS/Bcmd pathway as a dominant mediator of B cell survival, suggesting competition for BLyS/Bcmd signals regulates follicular B cell numbers. | lld:pubmed |
| pubmed-article:11747827 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747827 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747827 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11747827 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747827 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11747827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11747827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747827 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11747827 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11747827 | pubmed:issn | 0960-9822 | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:HayesC ECE | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:CancroM PMP | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:IkeA FAF | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:HilbertD MDM | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:LentzV MVM | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:SeoC SCS | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:Clise-DwyerKK | lld:pubmed |
| pubmed-article:11747827 | pubmed:author | pubmed-author:HarlessS MSM | lld:pubmed |
| pubmed-article:11747827 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11747827 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:11747827 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:11747827 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11747827 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11747827 | pubmed:pagination | 1986-9 | lld:pubmed |
| pubmed-article:11747827 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11747827 | pubmed:meshHeading | pubmed-meshheading:11747827... | lld:pubmed |
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| pubmed-article:11747827 | pubmed:meshHeading | pubmed-meshheading:11747827... | lld:pubmed |
| pubmed-article:11747827 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11747827 | pubmed:articleTitle | Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. | lld:pubmed |
| pubmed-article:11747827 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:11747827 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11747827 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11747827 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:72049 | entrezgene:pubmed | pubmed-article:11747827 | lld:entrezgene |
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