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pubmed-article:11747698pubmed:abstractTextOne hundred four serogroup A meningococci in our collection, isolated in Africa from 1988 to 1999, were characterized by multilocus sequence typing (MLST). Our results and data from the Internet indicate that sequence type 5 (ST-5) strains were responsible for most of African outbreaks and sporadic cases during this period. In 1995, a new clone, characterized by ST-7 sequence, emerged and was responsible for severe outbreaks in Chad (1998) and Sudan (1999). MLST and epidemiologic data indicate that ST-5 and ST-7 represent two virulent clones. These two STs, which belong to subgroup III, differ only in the pgm locus: allele pgm3 is characteristic for ST-5 and allele pgm19 for ST-7. Subgroup III strains were responsible for two pandemics in the 1960s and 1980s. Our data show that the third subgroup III pandemic has now reached Africa.lld:pubmed
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pubmed-article:11747698pubmed:articleTitleClonal expansion of sequence type (ST-)5 and emergence of ST-7 in serogroup A meningococci, Africa.lld:pubmed
pubmed-article:11747698pubmed:affiliationInstitut de Médecine Tropicale du Service de Santé des Armées, World Organization Collaborating Center, Marseille Armées, France. imtssa.meningo.free.frlld:pubmed
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