| pubmed-article:11747616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0887808 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0205430 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11747616 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11747616 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11747616 | pubmed:dateCreated | 2001-12-18 | lld:pubmed |
| pubmed-article:11747616 | pubmed:abstractText | The determination of a list of differentially expressed genes is a basic objective in many cDNA microarray experiments. We present a statistical approach that allows direct control over the percentage of false positives in such a list and, under certain reasonable assumptions, improves on existing methods with respect to the percentage of false negatives. The method accommodates a wide variety of experimental designs and can simultaneously assess significant differences between multiple types of biological samples. Two interconnected mixed linear models are central to the method and provide a flexible means to properly account for variability both across and within genes. The mixed model also provides a convenient framework for evaluating the statistical power of any particular experimental design and thus enables a researcher to a priori select an appropriate number of replicates. We also suggest some basic graphics for visualizing lists of significant genes. Analyses of published experiments studying human cancer and yeast cells illustrate the results. | lld:pubmed |
| pubmed-article:11747616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11747616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747616 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11747616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11747616 | pubmed:issn | 1066-5277 | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:GibsonGG | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:BennettLL | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:PaulesR SRS | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:BusherJJ | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:WolfingerE... | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:WolfingerR... | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:AfshariCC | lld:pubmed |
| pubmed-article:11747616 | pubmed:author | pubmed-author:HamadehHH | lld:pubmed |
| pubmed-article:11747616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11747616 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11747616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11747616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11747616 | pubmed:pagination | 625-37 | lld:pubmed |
| pubmed-article:11747616 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:meshHeading | pubmed-meshheading:11747616... | lld:pubmed |
| pubmed-article:11747616 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11747616 | pubmed:articleTitle | Assessing gene significance from cDNA microarray expression data via mixed models. | lld:pubmed |
| pubmed-article:11747616 | pubmed:affiliation | SAS Institute Inc., Cary, NC 27513, USA. russ.wolfinger@sas.com | lld:pubmed |
| pubmed-article:11747616 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11747616 | lld:pubmed |
