| pubmed-article:11741491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C0220908 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C0282534 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:11741491 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:11741491 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:11741491 | pubmed:dateCreated | 2001-12-19 | lld:pubmed |
| pubmed-article:11741491 | pubmed:abstractText | Structure-based in-silico screening was carried out for the Syk C-terminal SH2 domain. Fragments that could interact with the pY or pY+1 pockets were selected by our in-silico screening. After tethering two fragments bound to these pockets, we have designed and synthesized new compounds that show favorable interaction with the pY+3 pocket. One such compound, having a cyclohexylmalonic acid moiety identified as a novel potent phosphotyrosyl mimetic, exhibited an affinity comparable to that of the monophosphorylated ligand peptide. | lld:pubmed |
| pubmed-article:11741491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11741491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11741491 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11741491 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:TanakaAA | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:TsukamotoSS | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:KikuchiKK | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:MaedaYY | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:NiimiTT | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:FujitaSS | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:SakamotoSS | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:IchikawaAA | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:TatsutaKK | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:OritaMM | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:BallEE | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:SakashitaHH | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:YamagiwaYY | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:ChikauchiKK | lld:pubmed |
| pubmed-article:11741491 | pubmed:author | pubmed-author:Okazawa-Igara... | lld:pubmed |
| pubmed-article:11741491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11741491 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:11741491 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:11741491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11741491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11741491 | pubmed:pagination | 4737-40 | lld:pubmed |
| pubmed-article:11741491 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:meshHeading | pubmed-meshheading:11741491... | lld:pubmed |
| pubmed-article:11741491 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11741491 | pubmed:articleTitle | Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening. | lld:pubmed |
| pubmed-article:11741491 | pubmed:affiliation | Department of Applied Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan. tatsuta@mn.waseda.ac.jp | lld:pubmed |
| pubmed-article:11741491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11741491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11741491 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11741491 | lld:pubmed |
