| pubmed-article:11739287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11739287 | lifeskim:mentions | umls-concept:C0038125 | lld:lifeskim |
| pubmed-article:11739287 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:11739287 | lifeskim:mentions | umls-concept:C0206588 | lld:lifeskim |
| pubmed-article:11739287 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11739287 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:11739287 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11739287 | pubmed:dateCreated | 2001-12-12 | lld:pubmed |
| pubmed-article:11739287 | pubmed:abstractText | Ror alpha is an orphan nuclear receptor. In homozygous staggerer mutant mice (Ror alpha(sg/sg)), a deletion within the Ror alpha gene leads to an overexpression of inflammatory cytokines. Because inflammation and hypoxia are 2 key stimuli of ischemia-induced angiogenesis, we studied the role of Ror alpha in this setting. Ischemia was induced by ligation of the right femoral artery in C57BL/6 Ror alpha(+/+) and Ror alpha(sg/sg) mice. After 3 and 28 days, angiogenesis was evaluated by microangiography, measurement of capillary density using immunohistochemistry (anti-CD31), and measurement of blood flow by laser Doppler imaging. At day 3, angiographic score and blood flow were similar in Ror alpha(sg/sg) mice and in Ror alpha(+/+) littermates. Conversely, at day 28, Ror alpha(sg/sg) mice showed a significant 2-fold increase in angiographic score and a 3-fold increase in capillary density within the ischemic hindlimb compared with control. Functionally, this coincided with a significant rise in leg perfusion in Ror alpha(sg/sg) mice (0.83+/-0.05 for ischemic/nonischemic leg perfusion ratio) compared with Ror(+/+) mice (0.66+/-0.04, P<0.05). In addition, more extensive angiogenesis in Ror alpha(sg/sg) mice correlated with an increased expression of eNOS protein by 83+/-12% and 71+/-24% at 3 and 28 days, respectively (P<0.05), whereas the level of the antiangiogenic cytokine IL-12 was significantly reduced by 38+/-10% at day 28 (P<0.05). Conversely, no changes in VEGF expression were observed. Our study identifies for the first time a new role for Ror alpha as a potent negative regulator of ischemia-induced angiogenesis. | lld:pubmed |
| pubmed-article:11739287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11739287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11739287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11739287 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11739287 | pubmed:issn | 1524-4571 | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:MarianiJJ | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:DurieuHH | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:LevyB IBI | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:TedguiAA | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:Lemaigre-Dubr... | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:SilvestreJ... | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:BesnardSS | lld:pubmed |
| pubmed-article:11739287 | pubmed:author | pubmed-author:BakoucheJJ | lld:pubmed |
| pubmed-article:11739287 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11739287 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:11739287 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:11739287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11739287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11739287 | pubmed:pagination | 1209-15 | lld:pubmed |
| pubmed-article:11739287 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:meshHeading | pubmed-meshheading:11739287... | lld:pubmed |
| pubmed-article:11739287 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11739287 | pubmed:articleTitle | Increased ischemia-induced angiogenesis in the staggerer mouse, a mutant of the nuclear receptor Roralpha. | lld:pubmed |
| pubmed-article:11739287 | pubmed:affiliation | INSERM U541, Hôpital Lariboisière, and IFR Circulation-Paris 7, Université Paris 7-Denis Diderot, France. | lld:pubmed |
| pubmed-article:11739287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11739287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19883 | entrezgene:pubmed | pubmed-article:11739287 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11739287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11739287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11739287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11739287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11739287 | lld:pubmed |
