| pubmed-article:11736649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0162745 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:11736649 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11736649 | pubmed:issue | Pt 3 | lld:pubmed |
| pubmed-article:11736649 | pubmed:dateCreated | 2001-12-12 | lld:pubmed |
| pubmed-article:11736649 | pubmed:abstractText | The activator protein 1 (AP-1) transcription factor is composed of heterodimers of the Fos/activating transcription factor (ATF) and Jun subfamilies of basic-region leucine-zipper (B-ZIP) proteins. In order to determine the identities of individual B-ZIP proteins in various AP-1 complexes we tested the effect of dominant-negative mutants to the B-ZIP proteins c-Fos, ATF2, ATF4 and CCAAT-enhancer-binding protein (C/EBP) on the activities of the collagenase and c-Jun promoters. These dominant-negative mutants inhibit DNA binding of wild-type B-ZIP proteins in a leucine-zipper-dependent fashion. Transcription of a collagenase promoter/reporter gene was induced in HepG2 hepatoma cells by expression of c-Fos and c-Jun, administration of PMA ("TPA") or by expression of a truncated form of MEK (mitogen-activated/extracellular-signal-regulated kinase kinase) kinase-1, MEKK1Delta. In all cases, the dominant-negative mutants A-Fos and A-ATF2 decreased collagenase promoter activity. However, A-ATF4 and A-C/EBP had no effect. A-Fos and A-ATF2 also reduced MEKK1Delta-induced stimulation of the c-Jun promoter. In contrast, constitutive c-Jun promoter activity was blocked solely by A-ATF2, strongly suggesting that ATF2 and/or an ATF2-dimerizing protein are of major importance for c-Jun transcription in unstimulated cells. These results demonstrate that AP-1 transcription factors of different compositions control c-jun gene transcription in resting or stimulated cells. | lld:pubmed |
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| pubmed-article:11736649 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11736649 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11736649 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11736649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11736649 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11736649 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:11736649 | pubmed:author | pubmed-author:ThielGG | lld:pubmed |
| pubmed-article:11736649 | pubmed:author | pubmed-author:SteinmüllerLL | lld:pubmed |
| pubmed-article:11736649 | pubmed:author | pubmed-author:VinsonCC | lld:pubmed |
| pubmed-article:11736649 | pubmed:author | pubmed-author:CibelliGG | lld:pubmed |
| pubmed-article:11736649 | pubmed:author | pubmed-author:MollJ RJR | lld:pubmed |
| pubmed-article:11736649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11736649 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11736649 | pubmed:volume | 360 | lld:pubmed |
| pubmed-article:11736649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11736649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11736649 | pubmed:pagination | 599-607 | lld:pubmed |
| pubmed-article:11736649 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:11736649 | pubmed:meshHeading | pubmed-meshheading:11736649... | lld:pubmed |
| pubmed-article:11736649 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11736649 | pubmed:articleTitle | Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. | lld:pubmed |
| pubmed-article:11736649 | pubmed:affiliation | Department of Medical Biochemistry and Molecular Biology, Building 44, University of Saarland, D-66421 Homburg, Germany. | lld:pubmed |
| pubmed-article:11736649 | pubmed:publicationType | Journal Article | lld:pubmed |
