| pubmed-article:11727828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C1120843 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C1334475 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C1426212 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11727828 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11727828 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11727828 | pubmed:dateCreated | 2001-11-30 | lld:pubmed |
| pubmed-article:11727828 | pubmed:abstractText | In this study we show that activation of p38MAPK by IL-6 acts as an inhibitory signal on IL-6-mediated activation of STAT and the alpha2-macroglobulin promoter. We analyzed the role of MKK6/p38MAPK for IL-6 signal transduction and transcriptional activation of the suppressor of cytokine signaling (SOCS) 3 promoter. Pretreatment of cells with the p38MAPK-specific inhibitor SB202190 downregulates the induction of SOCS3-mRNA expression by IL-6. Accordingly, overexpression of a constitutively active MKK6 in HepG2 cells enhanced basal activity or IL-6-induced transcriptional activation of a SOCS3 promoter reporter construct, whereas overexpression of a dominant negative mutant of MKK6 downregulated the IL-6-mediated activation of the SOCS3 promoter. These data indicate that p38MAPK-activation is crucial for IL-6-induced SOCS3 expression and downregulation of IL-6-mediated gene induction. | lld:pubmed |
| pubmed-article:11727828 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11727828 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11727828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11727828 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11727828 | pubmed:issn | 1431-6730 | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:HeinrichP CPC | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:MelmedSS | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:LudwigSS | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:HäussingerDD | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:FreitasC ACA | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:TuckA BAB | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:SchaperFF | lld:pubmed |
| pubmed-article:11727828 | pubmed:author | pubmed-author:BodeJ GJG | lld:pubmed |
| pubmed-article:11727828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11727828 | pubmed:volume | 382 | lld:pubmed |
| pubmed-article:11727828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11727828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11727828 | pubmed:pagination | 1447-53 | lld:pubmed |
| pubmed-article:11727828 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11727828 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11727828 | pubmed:articleTitle | The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. | lld:pubmed |
| pubmed-article:11727828 | pubmed:affiliation | Klinik für Gastroenterologie, Hepatologie und Infektiologie, Medizinische Klinik der Heinrich-Heine Universität, Düsseldorf, Germany. | lld:pubmed |
| pubmed-article:11727828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11727828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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