| pubmed-article:11717450 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C0227354 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C1414506 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11717450 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:11717450 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:11717450 | pubmed:dateCreated | 2001-11-21 | lld:pubmed |
| pubmed-article:11717450 | pubmed:abstractText | The proteinase-activated receptor 2 (PAR-2) is a member of a family of G protein-coupled receptors for proteases. Proteases cleave PARs within the extracellular N-terminal domains to expose tethered ligands that bind to and activate the cleaved receptors. PAR-2 is highly expressed in colon in epithelial and neuronal elements. In this study we show that PAR-2 activation prevents the development and induces healing of T helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. A role for PAR-2 in the protection against colon inflammation was explored by the use of SLIGRL-NH(2), a synthetic peptide that corresponds to the mouse tethered ligand exposed after PAR-2 cleavage. TNBS-induced colitis was dose-dependently reduced by the administration of SLIGRL-NH(2), whereas the scramble control peptide, LSIGRL-NH(2), was uneffective. This beneficial effect was reflected by increased survival rates, improvement of macroscopic and histologic scores, decrease in mucosal content of T helper cell type 1 cytokines, protein, and mRNA, and a diminished myeloperoxidase activity. SLIGRL-NH(2), but not the scramble peptide, directly inhibited IFN-gamma secretion and CD44 expression on lamina propria T lymphocytes. Protection exerted by PAR-2 in TNBS-treated mice was reverted by injecting mice with a truncated form of calcitonin gene-related peptide and by sensory neurons ablation with the neurotoxin capsaicin. Collectively, these studies show that PAR-2 is an anti-inflammatory receptor in the colon and suggest that PAR-2 ligands might be effective in the treatment of inflammatory bowel diseases. | lld:pubmed |
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| pubmed-article:11717450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11717450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11717450 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11717450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11717450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11717450 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11717450 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:MorelliAA | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:HollenbergM... | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:WallaceJ LJL | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:MencarelliAA | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:FiorucciSS | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:DistruttiEE | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:CirinoGG | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:VergnolleNN | lld:pubmed |
| pubmed-article:11717450 | pubmed:author | pubmed-author:PalazzettiBB | lld:pubmed |
| pubmed-article:11717450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11717450 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:11717450 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11717450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11717450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11717450 | pubmed:pagination | 13936-41 | lld:pubmed |
| pubmed-article:11717450 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11717450 | pubmed:meshHeading | pubmed-meshheading:11717450... | lld:pubmed |
| pubmed-article:11717450 | pubmed:meshHeading | pubmed-meshheading:11717450... | lld:pubmed |
| pubmed-article:11717450 | pubmed:meshHeading | pubmed-meshheading:11717450... | lld:pubmed |
| pubmed-article:11717450 | pubmed:meshHeading | pubmed-meshheading:11717450... | lld:pubmed |
