| pubmed-article:11714738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11714738 | lifeskim:mentions | umls-concept:C0032276 | lld:lifeskim |
| pubmed-article:11714738 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11714738 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:11714738 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11714738 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11714738 | pubmed:dateCreated | 2001-11-20 | lld:pubmed |
| pubmed-article:11714738 | pubmed:abstractText | Host defenses are profoundly compromised in HIV-infected hosts due to progressive depletion of CD4+ T lymphocytes. Moreover, deficient CD4+ T lymphocytes impair vaccination approaches to prevent opportunistic infection. Therefore, we investigated a CD4+ T cell-independent vaccine approach to a prototypic AIDS-defining infection, Pneumocystis carinii (PC) pneumonia. Here, we demonstrate that bone marrow-derived dendritic cells (DCs) expressing the murine CD40 ligand, when pulsed ex vivo by PC antigen, elicited significant titers of anti-PC IgG in CD4-deficient mice. Vaccinated animals demonstrated significant protection from PC infection, and this protection was the result of an effective humoral response, since adoptive transfer of CD4-depleted splenocytes or serum conferred this protection to CD4-deficient mice. Western blot analysis of PC antigen revealed that DC-vaccinated, CD4-deficient mice predominantly reacted to a 55-kDa PC antigen. These studies show promise for advances in CD4-independent vaccination against HIV-related pathogens. | lld:pubmed |
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| pubmed-article:11714738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11714738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11714738 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11714738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11714738 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11714738 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:MarreroLL | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:WallachSS | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:YiLL | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:ZhengMM | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:KollsJ KJK | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:ShellitoJ EJE | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:ZhongQQ | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:Schwarzenberg... | lld:pubmed |
| pubmed-article:11714738 | pubmed:author | pubmed-author:JulianSS | lld:pubmed |
| pubmed-article:11714738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11714738 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:11714738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11714738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11714738 | pubmed:pagination | 1469-74 | lld:pubmed |
| pubmed-article:11714738 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11714738 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11714738 | pubmed:articleTitle | CD4+ T cell-independent vaccination against Pneumocystis carinii in mice. | lld:pubmed |
| pubmed-article:11714738 | pubmed:affiliation | Section of Pulmonary and Critical Care, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. | lld:pubmed |
| pubmed-article:11714738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11714738 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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