| pubmed-article:11699059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0033085 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0577559 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0381451 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11699059 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:11699059 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11699059 | pubmed:dateCreated | 2001-11-7 | lld:pubmed |
| pubmed-article:11699059 | pubmed:abstractText | We demonstrate that a high-fructose diet reduces the incidence of diabetes in nonobese diabetic (NOD) mice (31.2% v 57.1% on regular chow (RC); P =.009). In a second cohort of mice, we evaluated potential mechanisms for the protective effect of the high-fructose (HF) diet and whether the metabolic changes are strain-specific. Sixty NOD and 60 Balb/c mice were randomized at weaning into HF- and RC-fed groups (30 mice each) and followed for 28 weeks. Glucose tolerance testing demonstrated improved glucose tolerance in HF diet groups (P =.001 in Balb/c; P =.04 in NOD mice at 6 months). beta-cell mass was preserved in NOD mice on the HF diet, but remained unchanged in Balb/c mice. In NOD mice, hepatic insulin receptor substrate (IRS)-2 protein expression increased by 2-fold (P =.01 for 2 v 6 months) in HF-fed mice and was 53% +/- 15% higher (P =.01) in the HF diet versus RC groups at 6 months of age. IRS-2 expression was also increased in skeletal muscle of NOD mice and in both liver and muscle of Balb/c mice. Our data suggest that a HF diet improves glucose tolerance in both NOD and Balb/c mice. The improved glucose tolerance may be related to increased IRS-2 expression and, in NOD mice, preservation of beta-cell mass. | lld:pubmed |
| pubmed-article:11699059 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11699059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11699059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11699059 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11699059 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:JacksonR ARA | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:Bonner-WeirSS | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:PattiM EME | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:OrbanTT | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:WeitgasserRR | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:RuanZZ | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:LandakerEE | lld:pubmed |
| pubmed-article:11699059 | pubmed:author | pubmed-author:CordemanT PTP | lld:pubmed |
| pubmed-article:11699059 | pubmed:copyrightInfo | Copyright 2001 by W.B. Saunders Company | lld:pubmed |
| pubmed-article:11699059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11699059 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:11699059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11699059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11699059 | pubmed:pagination | 1369-76 | lld:pubmed |
| pubmed-article:11699059 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11699059 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11699059 | pubmed:articleTitle | High-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression. | lld:pubmed |
| pubmed-article:11699059 | pubmed:affiliation | Section on Immunology, Joslin Diabetes Center, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:11699059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11699059 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11699059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
