| pubmed-article:11694542 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11694542 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:11694542 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:11694542 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:11694542 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:11694542 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11694542 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11694542 | pubmed:dateCreated | 2002-1-7 | lld:pubmed |
| pubmed-article:11694542 | pubmed:abstractText | We have previously shown that CD4 ligand binding inhibits LFA-1-dependent adhesion between CD4+ T cells and B cells in a p56(lck)- and phosphatidylinositol 3-kinase (PI3-kinase)-dependent manner. In this work, downstream events associated with adhesion inhibition have been investigated. By using HUT78 T cell lines, CD4 ligands were shown to induce a dissociation of LFA-1 from cytohesin, a cytoplasmic protein known to bind LFA-1 and to enhance the affinity/avidity of LFA-1 for its ligand ICAM-1. A dissociation of PI3-kinase from cytohesin is also observed. In parallel, we have found that CD4 ligand binding induced a redistribution of PI3-kinase and of the tyrosine phosphatase SHP-2 to the membrane and induced a transient formation of protein interactions including PI3-kinase; an adaptor protein, Gab2; SHP-2; and a SH2 domain-containing inositol phosphatase, SHIP. By using antisense oligonucleotides or transfection of transdominant mutants, down-regulation of adhesion was shown to require the Gab2/PI3-kinase association and the expression of SHIP and SHP-2. We therefore propose that CD4 ligands, by inducing these molecular associations, lead to sustained local high levels of D-3 phospholipids and possibly regulate the cytohesin/LFA-1 association. | lld:pubmed |
| pubmed-article:11694542 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11694542 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11694542 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11694542 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11694542 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11694542 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11694542 | pubmed:author | pubmed-author:MazerollesFab... | lld:pubmed |
| pubmed-article:11694542 | pubmed:author | pubmed-author:BarbatChristi... | lld:pubmed |
| pubmed-article:11694542 | pubmed:author | pubmed-author:TrucyMaylisM | lld:pubmed |
| pubmed-article:11694542 | pubmed:author | pubmed-author:KolanusWaldem... | lld:pubmed |
| pubmed-article:11694542 | pubmed:author | pubmed-author:FischerAlainA | lld:pubmed |
| pubmed-article:11694542 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11694542 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:11694542 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11694542 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11694542 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11694542 | pubmed:pagination | 1276-83 | lld:pubmed |
| pubmed-article:11694542 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11694542 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11694542 | pubmed:articleTitle | Molecular events associated with CD4-mediated Down-regulation of LFA-1-dependent adhesion. | lld:pubmed |
| pubmed-article:11694542 | pubmed:affiliation | INSERM U 429, Bat. Kirmisson, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France. mazerol@necker.fr | lld:pubmed |
| pubmed-article:11694542 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11694542 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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